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Updated: Jan 28, 2026

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
Image-guided cancer therapy using aptamer-functionalized cross-linked magnetic-responsive Fe3O4@carbon nanoparticles
Changhong Zhao1, Xuebin Song1, Weiguang Jin2
1School of Life and Technology, Xinxiang Medical University, Xinxiang, Henan, 453003, PR China.
Abstract:
The excellent anticancer effect of combined differential cancer therapies has been observed in the last few decades. Efficient theragnostic nanoparticles (NPs) for malignancy treatment have received considerable research attention and widely investigated today. This study presents our results on the development of aptamer-functionalized Fe3O4@carbon@doxorubicin NPs (Apt-Fe3O4@C@DOX) and their application in the synergetic chemo-photothermal therapy (PTT) of cancer. The Apt-Fe3O4@C@DOX NPs displayed high photothermal conversion efficiency and extensive pH/heat-induced drug release. In vitro (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium) bromide experiments indicated that the combined chemo-PTT is much more toxic toward lung adenocarcinoma cells (A549) than PTT or chemotherapy alone. In addition, the Apt-Fe3O4@C@DOX NPs demonstrated decreasing contrast enhancement of magnetic resonance (MR) signals, which means they may be potentially applied as a contrast agent and serve as a critical component of T2-weighted MR imaging of tumor tissues. Taking the results together, the Apt-Fe3O4@C@DOX NPs show great potential for cancer therapy.
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