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Fatigue in Mastocytosis: A Case Series
1Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway.
Clinical Therapeutics
|February 25, 2019
Summary
Fatigue is common and severe in mastocytosis patients, worsening during attacks. Mast cells may be a key factor in fatigue, offering a potential therapeutic target.
Area of Science:
- Neuroscience
- Immunology
- Pathophysiology
Background:
- Chronic inflammatory diseases often involve brain mechanisms and proinflammatory cytokines causing fatigue.
- Mastocytosis, characterized by mast cell activation and bioactive substance release, shows a high prevalence of fatigue.
Observation:
- This case series explored triggers of mastocytosis attacks and their association with increased fatigue.
- Seven mastocytosis patients reported triggers like heat, cold, exercise, food, alcohol, and stress.
Findings:
- Patients reported significant fatigue, with median Visual Analog Scale scores of 80 during attacks and 40 between attacks.
- Fatigue severely impacted social, recreational, and occupational activities for most patients.
Implications:
- Fatigue is common and severe in mastocytosis, increasing during attacks.
- Mast cell-derived substances may directly contribute to fatigue pathophysiology.
- Mast cells represent a potential therapeutic target for fatigue in various conditions.
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