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Updated: Jan 28, 2026

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
Published on: June 16, 2017
DNA (Hydroxy)Methylation in T Helper Lymphocytes
1Institute for Research in Biomedicine and Università della Svizzera italiana, Via Vincenzo Vela 6, CH-6500 Bellinzona, Switzerland.
Abstract:
Upon recognition of an antigen, the differentiation of antigen-inexperienced naïve T lymphocytes into subsets able to effectively coordinate host defense is controlled by a network of transcription factors and regulatory molecules. In the cell nucleus, these factors act in the context of epigenetic modifications that influence DNA accessibility and ultimately gene expression. This review discusses recent findings about the role of DNA methylation (and its oxidized derivatives) in modulating the differentiation and functions of T helper lymphocytes of the adaptive immune system.
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