Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Local Attraction

Local Attraction

Local attraction refers to disturbances in compass readings caused by magnetic influences from nearby objects such as metal fences, buried pipes, vehicles, buildings, power lines, or natural iron ore deposits. Small items like wristwatches, steel tools, or belt buckles can also interfere with the compass by creating local magnetic fields that distort the Earth's natural magnetic field. These distortions lead to inaccurate readings, posing navigation and land surveying challenges.Local...

Local Anesthetics: Pharmacokinetics

Local Anesthetics: Pharmacokinetics

The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...

Local Anesthetics: Adverse Effects

Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...

Absolute and Local Extreme Values

Absolute and Local Extreme Values

The highest and lowest values of a function, relative to a reference axis, are known as extreme values. These include absolute maximum and absolute minimum values, which represent the highest and lowest points the function reaches across its entire domain. Within a restricted portion of the function, the highest and lowest values are referred to as local maximum and local minimum values, respectively.Periodic functions, such as sine and cosine, show extreme values at infinitely many points due...

Nuclear Localization Signals and Import

Nuclear Localization Signals and Import

Proteins targeted to the nucleus carry short stretches of amino acid sequences called the nuclear localization signal or NLS. Classical nuclear localization signals are of two types: monopartite and bipartite NLS. Monopartite classical NLS (cNLS) consists of a single cluster of 4-8 amino acids. Bipartite cNLS consists of two clusters of 2-3 amino acids and a 9-12 residue long proline-rich linker bridging the two clusters. Signal clusters are rich in positively charged amino acids such as...

Local Anesthetics: Mechanism of Action

Local Anesthetics: Mechanism of Action

Local anesthetics (LAs) block sensory and motor impulses by inhibiting the sodium channels on the nerve cell membranes. This induces temporary loss of sensation, relieving pain in a specific body area.
Local anesthetics are amphiphilic molecules consisting of a hydrophobic aromatic part linked to a hydrophilic group by an ester or amide linkage. They are weak bases and are usually available as salts, which increases their solubility and stability. Once administered, LAs exist in the body either...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Matrix extension to bovine feces and evaluation of semi-automated DNA extraction methods for the detection of <i>Campylobacter jejuni</i> in bovine and canine fecal samples using <i>gyrA</i> PCR.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2026

Same author

Inter-laboratory optimization for the detection of <i>Campylobacter jejuni</i> in canine fecal samples using <i>gyrA</i> PCR.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2026

Same author

A Blockchain-Enhanced Neural Network Framework for secure e-waste forecasting in smart cities.

Frontiers in public health·2026

Same author

Comparison of PCR and culture for detection of <i>Campylobacter jejuni</i> in canine feces.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2026

Same author

NCCN Guidelines® Insights: Small Cell Lung Cancer, Version 2.2026.

Journal of the National Comprehensive Cancer Network : JNCCN·2026

Same author

Loss of Payload Sensitivity and Other Mechanisms of Resistance to T-DXd in HER2-Mutant NSCLC: Implications for Subsequent Responsiveness to HER2 TKIs.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer·2026

Search research articles

Related Experiment Video

Updated: Jan 28, 2026

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

Revisiting localized malignant mesothelioma.

Shannon Mann¹, Sidrah Khawar², Cesar Moran²

¹St. Josephs Hospital, Tampa, FL, USA.

Annals of Diagnostic Pathology

|February 25, 2019

Summary

This summary is machine-generated.

Localized malignant mesothelioma, a rare presentation of this uncommon tumor, can mimic benign conditions. This diagnostic challenge requires careful clinicopathologic evaluation to avoid misdiagnosis in both pathologists and radiologists.

Keywords:

Localized malignant mesothelioma Malignant mesothelioma Tumors of pleura

More Related Videos

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish

Published on: February 22, 2019

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Related Experiment Videos

Last Updated: Jan 28, 2026

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish

Published on: February 22, 2019

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Area of Science:

Oncology
Pathology
Radiology

Background:

Malignant mesothelioma is typically a diffuse pleural tumor with a poor prognosis.
Rarely, malignant mesothelioma can manifest as a localized, circumscribed mass or focal pleural lesion.

Observation:

This study identified four cases of localized malignant mesothelioma in the database.
Three cases were localized epithelioid malignant mesothelioma, and one was localized sarcomatoid mesothelioma.

Findings:

Localized malignant mesothelioma presents a diagnostic pitfall for pathologists and radiologists.
These focal lesions can be mistaken for other pleural abnormalities, complicating diagnosis.

Implications:

Awareness of this rare presentation is crucial for accurate diagnosis.
Further research into the clinicopathologic features of localized mesothelioma is warranted.
Improved diagnostic strategies are needed to differentiate localized mesothelioma from other pleural masses.