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Updated: Jan 28, 2026

DNA Sequence Recognition by DNA Primase Using High-Throughput Primase Profiling
Published on: October 8, 2019
A comparison of software for the evaluation of complex DNA profiles
1Melbourne Integrative Genomics, School of BioSciences and School of Mathematics and Statistics, University of Melbounrne, Parkville, 3010, VIC, Australia.
Abstract:
We compare two open-source programs for the evaluation of evidential weight arising from complex DNA profiles recovered in a crime investigation. Here, "complex" means one or more of: low-template, degraded and mixed-source. Although software for complex DNA profile analysis has made great strides in recent years, the ability of courts to effectively scrutinise and challenge the reliability of the resulting evidence remains problematic. One key step is to compare different software on the same evidence, but there are currently few published comparisons in part because of the problems posed by restricted access to commercial software. We present here an extensive comparison between two open-source software, LikeLTD and EuroForMix. We find that despite different modelling assumptions the two programs generate similar results. The differences that we do identify can inform future improvements and can provide a benchmark for acceptable discrepancies between alternative programs.
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