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Phyllanthus taxodiifolius Beille suppresses microtubule dynamics and restricts glioblastoma aggressiveness

Jaturon Kwanthongdee1, Chotchanit Sunrat1, Bamroong Munyoo2

  • 1Department of Physiology, Faculty of Science, Mahidol University, Rama VI Rd, Bangkok, Thailand.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|February 25, 2019
PubMed

Insights

Phyllanthus taxodiifolius extract combats glioblastoma invasion by disrupting cell adhesion and migration. This plant extract shows potential as a novel anti-cancer agent targeting microtubule dynamics in brain tumors.

Area of Science:

  • Oncology
  • Pharmacology
  • Cell Biology

Background:

  • Glioblastoma is a highly malignant brain tumor with poor prognosis due to invasive cell growth.
  • Current treatments are limited in overcoming glioma cell invasion, necessitating new therapeutic strategies.
  • Phyllanthus taxodiifolius (P. taxodiifolius) exhibits anti-cancer properties, but its effects on glioblastoma remain unexplored.

Purpose of the Study:

  • To investigate the effects of P. taxodiifolius extract on glioblastoma cell aggressive properties, including adhesion, migration, and invasion.
  • To elucidate the underlying molecular mechanisms by which P. taxodiifolius extract affects glioblastoma cells.
  • To assess the potential of P. taxodiifolius as a therapeutic agent against glioblastoma invasion.

Main Methods:

  • Treatment of glioblastoma cells with P. taxodiifolius extract.
  • Assessment of cell adhesion, migration, and invasion assays.
  • Live imaging of microtubule dynamics and analysis of focal adhesion kinase activity.

Main Results:

  • P. taxodiifolius extract significantly disrupted glioblastoma cell adhesion.
  • The extract demonstrated a delay in cell migration and interfered with invasion.
  • Suppression of microtubule dynamics and decreased focal adhesion kinase activity were observed.

Conclusions:

  • P. taxodiifolius extract effectively suppresses the invasive properties of glioblastoma cells.
  • The extract acts by disrupting microtubule structure and dynamics.
  • P. taxodiifolius and its compounds represent a promising avenue for developing novel glioblastoma therapies targeting microtubules.
Keywords:
AnticancerGlioblastomaInvasionMicrotubulesMigrationPhyllanthus taxodiifolius Beille

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