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Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang1, Jianhui Wu1, Xiuyun Tian1

  • 1Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Hepato-Pancreato-Biliary Surgery, Peking University Cancer Hospital and Institute, Beijing, 100142, China.

Frontiers of Medicine
|February 25, 2019
PubMed

Insights

Targeted therapy for desmoid-type fibromatosis (DF) shows limited advantages over other treatments. Further research is needed to clarify its role, dosage, and mechanisms in managing this rare fibroblastic tumor.

Area of Science:

  • Oncology
  • Dermatology
  • Medical Research

Background:

  • Desmoid-type fibromatosis (DF) is a rare, locally infiltrative fibroblastic tumor.
  • Current targeted therapies, including tyrosine kinase and γ-secretase inhibitors, lack robust evidence due to small retrospective studies.

Purpose of the Study:

  • To review existing literature on the mechanism, efficacy, and safety of targeted therapies for DF.
  • To compare targeted therapy with other systemic treatments for DF.

Main Methods:

  • Systematic review of previous studies on DF targeted therapy.
  • Comparative analysis of efficacy and safety data between targeted and other systemic therapies.

Main Results:

  • Targeted therapy for DF does not demonstrate significant advantages in efficacy or safety compared to other medical treatments.
  • Targeted therapy is typically reserved for cases refractory to antihormonal therapies, NSAIDs, and chemotherapy.

Conclusions:

  • Current evidence does not support substantial benefits of targeted therapy over existing treatments for DF.
  • Further investigation into the mechanisms, indications, and optimal dosing of targeted DF therapies is essential.
Keywords:
desmoid-type fibromatosistargeted therapytyrosine kinase inhibitorγ-secretase inhibitor

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