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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
Published on: July 10, 2012
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Diagnosing and managing bronchiolitis obliterans in children
Ema Kavaliunaite1, Paul Aurora1,2
1a Respiratory Unit , Great Ormond Street Hospital for Children NHS Foundation Trust , London , UK.
Expert Review of Respiratory Medicine
|February 26, 2019
Summary
Bronchiolitis obliterans (BO) is a serious lung disease in children, often post-infectious. Current understanding of its development and effective treatments remains limited, necessitating expert care.
Area of Science:
- Pediatric Pulmonology
- Respiratory Medicine
Background:
- Bronchiolitis obliterans (BO) is a chronic, irreversible obstructive lung disease affecting small airways.
- Key entities include post-infectious BO (PIBO), and BO post lung or bone marrow transplantation (BMT/HSCT).
- Similarities in histopathology and development pathways exist across BO entities.
Purpose of the Study:
- To review current evidence on the diagnosis and management of bronchiolitis obliterans in children.
- To highlight diagnostic approaches and current treatment limitations.
Main Methods:
- Review of existing literature on pediatric bronchiolitis obliterans.
- Analysis of diagnostic criteria, including clinical, radiological, and histopathological findings.
- Evaluation of current treatment evidence, particularly for post-infectious BO.
Main Results:
- Diagnosis often combines clinical history, imaging, and sometimes lung biopsy.
- Understanding of BO development mechanisms is incomplete.
- Strong evidence for effective treatments is lacking, with most data from adult transplant patients.
Conclusions:
- Bronchiolitis obliterans management in children requires a multidisciplinary approach.
- Care should be centralized in specialized centers due to complexity and limited treatment options.
- Further research is needed to elucidate BO pathogenesis and develop targeted therapies.
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