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Aging, metabolic acidosis and renal failure: Interactive accelerating processes.

L A Frassetto1, A Sebastian1

  • 1University of California San Francisco, San Francisco CA, United States.

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Summary

A low acid diet, particularly one low in phosphate, may promote longevity and healthspan. Neutralizing metabolic acidosis associated with aging could potentially extend lifespan and improve health.

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Area of Science:

  • Gerontology
  • Nutritional Science
  • Metabolic Health

Background:

  • Aging is often associated with a low-grade metabolic acidosis.
  • Dietary acid load can influence metabolic processes.
  • Phosphate intake is a key factor in dietary acid load.

Purpose of the Study:

  • To hypothesize the beneficial effects of a low acid diet on aging.
  • To explore the role of base precursors like bicarbonate in mitigating age-related acidosis.
  • To suggest potential interventions for improving healthspan and lifespan.

Main Methods:

  • Review of existing studies in invertebrate and small animal models.
  • Extrapolation of findings to human aging.
  • Analysis of associated human study results.

Main Results:

  • Low acid and low phosphate diets show potential benefits for aging.
  • Dietary supplementation with base precursors (e.g., bicarbonate) may counteract metabolic acidosis.
  • Evidence suggests these dietary modifications could impact longevity and healthspan.

Conclusions:

  • Reducing dietary acid load may be a viable strategy to enhance healthy aging.
  • Neutralizing age-related metabolic acidosis could lead to increased lifespan.
  • Further research in human subjects is warranted to confirm these findings.