Related Experiment Video

Updated: Jan 28, 2026

Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis
11:08

Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis

Published on: June 19, 2018

10.2K

Targeting DNA repair in precision medicine

Reena Beggs1, Eddy S Yang2

  • 1Department of Radiation Oncology, University of Alabama-Birmingham School of Medicine, Birmingham, AL, United States.

Advances in Protein Chemistry and Structural Biology
|February 26, 2019
PubMed

Insights

Precision medicine revolutionizes cancer treatment by tailoring therapies to individual genetic profiles. Targeting DNA repair mechanisms offers a promising strategy within precision oncology.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Precision medicine aims to personalize treatment based on individual variability.
  • Cancer cells possess DNA repair mechanisms that can be exploited therapeutically.
  • Understanding DNA repair is crucial for developing targeted cancer therapies.

Purpose of the Study:

  • To review current strategies for targeting DNA repair pathways in cancer.
  • To highlight the role of DNA repair in precision oncology.
  • To discuss the application of precision medicine in cancer treatment.

Main Methods:

  • Review of current scientific literature on DNA repair pathways.
  • Analysis of precision oncology approaches targeting DNA repair.
  • Focus on genetic, environmental, and lifestyle factors.

Main Results:

  • DNA repair pathways are viable targets for cancer therapy.
  • Targeting DNA repair aligns with precision medicine principles.
  • Individualized treatment strategies can improve cancer outcomes.

Conclusions:

  • Targeting DNA repair is a key component of precision oncology.
  • Personalized approaches in cancer treatment are advancing rapidly.
  • Further research into DNA repair mechanisms will enhance targeted therapies.
Keywords:
DNA damageDNA repairHomologous recombinationPARPPersonalized medicinePrecision medicineTargeted therapy

More Related Videos

Culture of Bladder Cancer Organoids as Precision Medicine Tools08:39

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

5.4K
Visualization of DNA Repair Proteins Interaction by Immunofluorescence07:55

Visualization of DNA Repair Proteins Interaction by Immunofluorescence

Published on: June 26, 2020

11.0K

Related Concept Videos

Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
33.6K
Overview of DNA Repair02:25

Overview of DNA Repair

9.8K
Mismatch Repair01:36

Mismatch Repair

Overview
43.7K
Base-pairing and DNA Repair02:27

Base-pairing and DNA Repair

93.3K
Base Excision Repair01:54

Base Excision Repair

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
26.3K
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

Overview
40.8K