Related Experiment Video

Updated: Jan 28, 2026

Stress Distribution During Cold Compression of Rocks and Mineral Aggregates Using Synchrotron-based X-Ray Diffraction
10:36

Stress Distribution During Cold Compression of Rocks and Mineral Aggregates Using Synchrotron-based X-Ray Diffraction

Published on: May 20, 2018

10.1K

ENPP1 in the Regulation of Mineralization and Beyond

Fiona Roberts1, Dongxing Zhu2, Colin Farquharson1

  • 1The Roslin Institute, RDSVS, Easter Bush Campus, University of Edinburgh, Midlothian, EH25 9RG, UK.

Trends in Biochemical Sciences
|February 26, 2019
PubMed

Insights

Ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) regulates mineralization and contributes to diseases like diabetes and cancer. Understanding ENPP1

Area of Science:

  • Biochemistry
  • Pathology
  • Molecular Biology

Background:

  • Ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) is crucial for skeletal and soft tissue mineralization.
  • ENPP1 generates pyrophosphate, inhibiting hydroxyapatite formation.
  • ENPP1 is implicated in various human diseases, including diabetes, cancer, cardiovascular disease, and osteoarthritis.

Purpose of the Study:

  • To review the pathological roles of ENPP1 in mineralization and soft tissue disorders.
  • To elucidate the mechanisms underlying ENPP1's pathological effects.
  • To highlight the therapeutic potential of targeting ENPP1 pathways.

Main Methods:

  • Literature review of existing studies on ENPP1.
  • Analysis of ENPP1's role in disease pathogenesis.
  • Discussion of molecular mechanisms.

Main Results:

  • ENPP1 plays a significant role in pathological mineralization processes.
  • ENPP1 contributes to the development and progression of multiple chronic diseases.
  • Specific molecular pathways involving ENPP1 have been identified.

Conclusions:

  • ENPP1 is a key factor in mineralization and various diseases.
  • Targeting ENPP1 offers potential for novel therapeutic strategies.
  • Further research into ENPP1 mechanisms can advance treatment for common morbidities.
Keywords:
ENPP1cardiovascular diseasediabetesmineralizationpathological effects

More Related Videos

Author Spotlight: Advanced Techniques for Characterizing Tissue Mineralization in Bone Regeneration Research07:29

Author Spotlight: Advanced Techniques for Characterizing Tissue Mineralization in Bone Regeneration Research

Published on: September 27, 2024

1.2K
High-Throughput, Multi-Image Cryohistology of Mineralized Tissues10:18

High-Throughput, Multi-Image Cryohistology of Mineralized Tissues

Published on: September 14, 2016

17.0K

Related Concept Videos

Water and Mineral Acquisition02:34

Water and Mineral Acquisition

Specialized tissues in plant roots have evolved to capture water, minerals, and some ions from the soil. Roots exhibit a variety of branching patterns that facilitate this process. The outermost root cells have specialized structures called root hairs that increase the root surface, thus increasing soil contact. Water can passively cross into roots, as the concentration of water in the soil is higher than that of the root tissue. Minerals, in contrast, are actively transported into root cells.
35.6K
Minerals01:26

Minerals

Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
 
Major...
1.2K
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.7K
GTPases and their Regulation02:14

GTPases and their Regulation

Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...
9.8K
Regulated Protein Degradation02:58

Regulated Protein Degradation

It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
8.8K
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.8K