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Effects of Mirabegron on Anxiety and Depression in Female Patients with Overactive Bladder
Manami Kinjo1, Tsuyoshi Yamaguchi2, Mitsuhiro Tambo2
1Department of Urology, Kyorin University School of Medicine, Tokyo, Japan, kinjo_1702@yahoo.co.jp.
Background:
Treatment of overactive bladder (OAB) with antimuscarinic agents has been shown to improve depression and/or anxiety symptoms.
Objectives:
The aim of this study was to evaluate the efficacy of mirabegron on OAB symptoms and its effects on depression and/or anxiety of treatment-naïve women with OAB.
Methods:
Women treated with mirabegron were prospectively evaluated by the OAB symptom score and hospital anxiety and depression Scale before and at 4 and 8 weeks after treatment. Wilcoxon signed-rank and Spearman rank correlation coefficient were used for statistical analyses, and a p value of < 0.05 was considered as significant.
Results:
Of the 112 patients who were enrolled, 25.0% had been previously diagnosed as having clinical anxiety and 22.3% as having clinical depression. The OAB, anxiety, and depression symptom scores were significantly improved at both 4 and 8 weeks (p < 0.05). Anxiety, but not depression, symptoms were significantly correlated with OAB symptoms.
Conclusion:
Improvement of OAB symptoms helps relieve anxiety, but not depression.
Insights
Mirabegron effectively treated overactive bladder (OAB) symptoms, significantly improving anxiety in women. While OAB symptom improvement correlated with reduced anxiety, it did not significantly impact depression.
Area of Science:
- Urology
- Psychiatry
- Pharmacology
Background:
- Antimuscarinic agents for overactive bladder (OAB) may improve co-occurring depression and anxiety.
- Mirabegron is a beta-3 adrenergic agonist used for OAB treatment.
- The relationship between OAB symptom management and mental health requires further investigation.
Purpose of the Study:
- To assess mirabegron's efficacy on OAB symptoms in treatment-naïve women.
- To evaluate mirabegron's impact on anxiety and depression symptoms in this patient group.
- To explore correlations between OAB symptom improvement and changes in anxiety/depression.
Main Methods:
- Prospective evaluation of 112 women with OAB treated with mirabegron.
- Assessment using Overactive Bladder Symptom Score (OABSS) and Hospital Anxiety and Depression Scale (HADS) at baseline, 4, and 8 weeks.
- Statistical analysis included Wilcoxon signed-rank test and Spearman rank correlation.
Main Results:
- Significant improvements in OAB, anxiety, and depression symptom scores were observed at 4 and 8 weeks (p < 0.05).
- Prevalence of clinical anxiety and depression at baseline was 25.0% and 22.3%, respectively.
- Anxiety symptoms showed a significant correlation with OAB symptoms, but depression symptoms did not.
Conclusions:
- Mirabegron treatment improves OAB symptoms and associated anxiety.
- The study suggests that alleviating OAB symptoms can positively impact anxiety levels.
- Mirabegron's effect on depression symptoms in OAB patients warrants further research.
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