Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Trait and State Self-Esteem02:08

Trait and State Self-Esteem

11.5K
The term self-esteem is often used generically, to refer to how people feel about themselves. However, according to research, there are three distinct constructs that should not be used interchangeably (Brown & Marshall, 2006). 
11.5K
Protein Families02:47

Protein Families

16.8K
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
16.8K
Protein Families02:47

Protein Families

4.4K
4.4K
Gene Families01:57

Gene Families

9.9K
Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
9.9K
Gene Families01:57

Gene Families

3.8K
3.8K
Polygenic Traits01:18

Polygenic Traits

69.0K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
69.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Bayesian Learning Model for Joint Risk Prediction of Alcohol and Cannabis Use Disorders.

Statistics in medicine·2026
Same author

CBCRisk-Mastectomy: A Prediction Tool to Aid Contralateral Prophylactic Mastectomy Decision- making.

The Journal of surgical research·2026
Same author

Engineering copper nanoparticle/polysaccharide-immobilized cotton gauze for accelerated healing of <i>Staphylococcus aureus</i>-infected dermal wounds.

Journal of materials chemistry. B·2026
Same author

CBCRisk-Mastectomy: A Risk Prediction Tool to Aid Contralateral Prophylactic Mastectomy Decision Making.

medRxiv : the preprint server for health sciences·2026
Same author

Refining the Definition for "Low Risk" in Pulmonary Arterial Hypertension: Time to Reduce Morbidity and Mortality.

JACC. Heart failure·2026
Same author

Reply to Blette and Kawut: Surrogate Endpoints are Risky Business in Pulmonary Arterial Hypertension.

American journal of respiratory and critical care medicine·2026

Related Experiment Video

Updated: Jan 28, 2026

Quantitative Measurement of Relative Retinoic Acid Levels in E8.5 Embryos and Neurosphere Cultures Using the F9 RARE-Lacz Cell-based Reporter Assay
09:49

Quantitative Measurement of Relative Retinoic Acid Levels in E8.5 Embryos and Neurosphere Cultures Using the F9 RARE-Lacz Cell-based Reporter Assay

Published on: September 6, 2016

8.2K

A Family-Based Rare Haplotype Association Method for Quantitative Traits.

Ananda S Datta1, Shili Lin2, Swati Biswas3

  • 1Department of Mathematical Sciences, University of Texas at Dallas, Richardson, Texas, USA.

Human Heredity
|February 26, 2019
PubMed
Summary

A new method, family-based quantitative Bayesian LASSO (famQBL), effectively identifies rare haplotype variants (rHTVs) linked to quantitative traits. This approach offers improved power and controlled false-positive rates compared to existing family-based methods.

Keywords:
Bayesian LASSOBlood pressureFamily-based association testFramingham Heart StudyGenetic Analysis WorkshopMarkov chain Monte CarloQuantitative traits

More Related Videos

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

3.7K
An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

23.3K

Related Experiment Videos

Last Updated: Jan 28, 2026

Quantitative Measurement of Relative Retinoic Acid Levels in E8.5 Embryos and Neurosphere Cultures Using the F9 RARE-Lacz Cell-based Reporter Assay
09:49

Quantitative Measurement of Relative Retinoic Acid Levels in E8.5 Embryos and Neurosphere Cultures Using the F9 RARE-Lacz Cell-based Reporter Assay

Published on: September 6, 2016

8.2K
A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

3.7K
An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

23.3K

Area of Science:

  • Genetics
  • Statistical Genetics
  • Bioinformatics

Background:

  • Genome-wide association studies explain limited disease heritability, with rare variants potentially holding the key to "missing heritability."
  • Rare haplotype variants (rHTVs) are implicated in complex diseases, but existing population-based detection methods suffer from high false-positive rates due to stratification and admixture.
  • Family-based methods offer a more robust approach for identifying disease-associated variants.

Purpose of the Study:

  • To introduce a novel family-based method for detecting rare haplotype variants (rHTVs) associated with quantitative traits.
  • To address the limitations of existing population-based methods for rHTV detection.

Main Methods:

  • Development of the family-based quantitative Bayesian LASSO (famQBL) method, utilizing a mixed model framework.
  • Regularization of haplotype effects using Bayesian LASSO and estimation of posterior distributions via Markov chain Monte Carlo (MCMC) methods.
  • famQBL is designed to analyze diverse pedigree structures.

Main Results:

  • Simulation studies demonstrated that famQBL possesses higher statistical power and maintains well-controlled false-positive rates compared to the standard family-based association test (FBAT).
  • Application of famQBL to the Framingham Heart Study data successfully identified an rHTV associated with diastolic blood pressure.
  • Analysis of Genetic Analysis Workshop 18 simulated data validated the properties of famQBL.

Conclusions:

  • The proposed famQBL method is effective in uncovering rare haplotype variants associated with quantitative traits.
  • famQBL provides a powerful and reliable tool for genetic association studies, particularly for identifying the contribution of rare variants to complex diseases.