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Filamin A and DRD2 expression in corticotrophinomas
Thais Sickler1, Ericka Barbosa Trarbach1, Fernando Pereira Frassetto2
1Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clínicas & Laboratory of Cellular and Molecular Endocrinology LIM-25, University of Sao Paulo Medical School, São Paulo, SP, Brazil.
Pituitary
|February 26, 2019
Summary
In corticotrophinomas, filamin A (FLNA) and dopamine receptor type 2 (DRD2) expression did not correlate. FLNA expression may be linked to tumor invasiveness, but not to cabergoline response.
Area of Science:
- Endocrinology
- Oncology
- Molecular Biology
Background:
- Filamin A (FLNA) and dopamine receptor type 2 (DRD2) expression are linked in prolactinomas.
- Limited data exists on DRD2 and no data on FLNA in corticotrophinomas.
Purpose of the Study:
- To investigate FLNA and DRD2 expression in corticotrophinomas.
- To determine the association between FLNA, DRD2, and tumor characteristics.
- To explore the relationship with cabergoline treatment response.
Main Methods:
- Immunohistochemistry was used to evaluate DRD2 and FLNA expression in 23 corticotrophinoma samples.
- H-score (0-300) quantified protein expression.
- Cabergoline treatment response was assessed in six patients post-surgery.
Main Results:
- DRD2 was expressed in 89% of corticotrophinomas; no correlation with FLNA.
- FLNA expression was not associated with tumor size or clinical features, but showed a link to sphenoid sinus invasion.
- Cabergoline response (33% of cases) did not correlate with DRD2 or FLNA expression.
Conclusions:
- DRD2 and FLNA expression are not associated in corticotrophinomas.
- FLNA expression may indicate tumor invasiveness.
- Neither FLNA nor DRD2 expression predicts response to cabergoline therapy.
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