Related Experiment Video

Updated: Jan 28, 2026

Robot-Assisted Kidney Transplantation
07:30

Robot-Assisted Kidney Transplantation

Published on: July 19, 2021

4.3K

The Impact of Perioperative Factors on Changes in Diastolic Function after Kidney Transplantation: A Retrospective

Eun Jung Kim1,2, Bon Nyeo Koo1,2, So Yeon Kim1,2

  • 1Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Yonsei Medical Journal
|February 26, 2019
PubMed

Insights

Kidney transplantation improves cardiac diastolic function. Post-transplant renal function is key, but excessive intraoperative fluids can worsen diastolic dysfunction in some patients.

Area of Science:

  • Cardiology
  • Nephrology
  • Transplantation Medicine

Background:

  • Cardiac dysfunction, particularly diastolic dysfunction, is a significant concern in end-stage renal disease and a leading cause of mortality post-kidney transplantation (KT).
  • Chronic kidney disease is a known risk factor for developing and worsening diastolic dysfunction.
  • Left ventricular (LV) diastolic function assessment is crucial for managing cardiac health in KT candidates and recipients.

Purpose of the Study:

  • To investigate the association between alterations in left ventricular (LV) diastolic function and perioperative clinical factors in patients undergoing KT.
  • To specifically examine changes in LV diastolic function in patients with preserved ejection fraction after KT.
  • To identify predictive factors for diastolic function changes following kidney transplantation.

Main Methods:

  • Retrospective review of 115 patients who underwent KT between January 2011 and December 2015.
  • Inclusion criteria: availability of pre- and post-transplant echocardiograms; exclusion of patients with LV systolic dysfunction.
  • LV diastolic function was assessed using the ratio of early transmitral flow velocity to early diastolic velocity of the mitral annulus (E/e').

Main Results:

  • Patients with normal pre-operative LV systolic function (n=97) demonstrated significant improvement in E/e' post-KT (p=0.023).
  • Post-KT estimated glomerular filtration ratio was significantly associated with changes in E/e' (p=0.026).
  • In patients with pre-existing diastolic dysfunction (20/97), intraoperative fluid administration correlated with E/e' changes (p=0.029).

Conclusions:

  • Kidney transplantation is associated with improved left ventricular diastolic function.
  • Post-KT renal function is a significant determinant of changes in LV diastolic function.
  • Intraoperative fluid management is critical, as excessive administration can be a risk factor for worsening diastolic function in KT patients with prior diastolic dysfunction.
Abstract

Keywords:
Kidney transplantationdiastolic functionend-stage renal disease (ESRD)

More Related Videos

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

11.5K
Normothermic Machine Perfusion of Rat Kidneys for Transplantation10:42

Normothermic Machine Perfusion of Rat Kidneys for Transplantation

Published on: January 27, 2026

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
396
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
390
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
363
Kidney Structure01:45

Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
75.1K
Impact of Groups on Groups01:19

Impact of Groups on Groups

Social psychologists analyze how groups influence one another, shaping social structures and interactions through both cooperation and competition. These dynamics manifest in various ways, ranging from economic partnerships to intergroup conflicts that shape societal structures and perceptions.Cooperation and Competition in Intergroup RelationsIntergroup relationships vary across contexts, sometimes fostering cooperation and mutual benefit while at other times leading to conflict and...
241
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.7K