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Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

375
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
375
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

369
 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
369
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

308
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
308
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

396
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
396
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

414
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
414
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

1.1K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease
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Antithrombotics in stable peripheral artery disease.

Eric Kaplovitch1, Luke Rannelli2, Sonia S Anand3

  • 11 Department of Medicine, University of Toronto, Toronto, ON, Canada.

Vascular Medicine (London, England)
|February 26, 2019
PubMed
Summary
This summary is machine-generated.

For peripheral artery disease (PAD), rivaroxaban plus aspirin reduces cardiovascular and limb events without increasing bleeding. Single antiplatelet therapy is less effective in asymptomatic PAD.

Keywords:
anticoagulationantiplatelet therapyantithrombotic therapyatherosclerosisperipheral artery disease (PAD)vascular medicine

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Area of Science:

  • Vascular Medicine
  • Cardiology
  • Pharmacology

Background:

  • Peripheral artery disease (PAD) patients face high risks of ischemic cardiovascular complications.
  • Single antiplatelet therapy (SAPT) is the traditional treatment for stable PAD.
  • Over 40,000 PAD patients have been studied in antithrombotic trials.

Purpose of the Study:

  • To review current evidence on antithrombotics in stable PAD.
  • To compare rates of major adverse cardiovascular events (MACE), major adverse limb events (MALE), and bleeding.
  • To guide optimal antithrombotic regimen selection for PAD patients.

Main Methods:

  • Systematic review of randomized controlled trials in PAD patients.
  • Analysis of antithrombotic strategies including SAPT, dual antiplatelet therapy (DAPT), vitamin K antagonists, and rivaroxaban plus aspirin.
  • Focus on comparative efficacy and safety outcomes.

Main Results:

  • SAPT has limited use in asymptomatic PAD but prevents MACE in symptomatic PAD.
  • Dual antiplatelet therapy (DAPT) shows potential but is inconclusive regarding MACE/MALE reduction and increases bleeding.
  • Rivaroxaban 2.5 mg BID plus aspirin reduces MACE and MALE without increasing major bleeding, and lessens MALE severity.

Conclusions:

  • Optimal antithrombotic selection is crucial for managing PAD complications.
  • Rivaroxaban plus aspirin offers a favorable risk-benefit profile for reducing ischemic events in PAD.
  • Evidence synthesis aids vascular medicine practitioners in minimizing adverse events in PAD patients.