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Updated: Jan 28, 2026

Using Synchrotron Radiation Microtomography to Investigate Multi-scale Three-dimensional Microelectronic Packages
Published on: April 13, 2016
Ultrastructural Analysis of Human Gallstones using Synchrotron Radiation µCT
Weixin Chen1,2, Riming Liu3, Suo Tao4
1Department of General Surgery, The Second Affiliated Hospital of Soochow University, No.1055, Sanxiang Rd, Suzhou 215004, China.
Objective:
Gallstone formation is a pathological process of mineralization in the human body. Determination of the morphology and ultrastructure of gallstones holds the key to understanding the pathophysiology of gallbladder disease. Synchrotron radiation phase-contrast Xray microtomography is a novel technology, which is designed for comprehensive analysis of gallstone ultrastructure.
Materials And Methods:
Nine human gallstones were obtained from the Department of Pathology, Qingpu branch of Zhongshan Hospital Affiliated to Fudan University (China), and scanned by synchrotron radiation µCT (SR µCT). The imaging data generated by SR µCT scan were analyzed.
Results:
The three-dimensional ultrastructure of human gallstones corresponding to their cholesterol and bile pigment composition was determined.
Conclusions:
The ultrastructure of gallstones exhibits considerable diversity and complexity. The synchrotron radiation phase-contrast X-ray microtomography is a valuable tool for in-depth study of human gallstones.
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