Related Experiment Video

Updated: Jan 28, 2026

An In Vitro Model to Study the Effect of 5-Aminolevulinic Acid-mediated Photodynamic Therapy on Staphylococcus aureus Biofilm
05:12

An In Vitro Model to Study the Effect of 5-Aminolevulinic Acid-mediated Photodynamic Therapy on Staphylococcus aureus Biofilm

Published on: April 16, 2018

8.3K

Macular cutaneous amyloidosis treated with methyl aminolevulinate and daylight photodynamic therapy: A case report

Christina M Huang1,2, Lauren Lam2, Robert Gniadecki2

  • 1School of Medicine, Queen's University, Kingston, ON, Canada.

SAGE Open Medical Case Reports
|February 26, 2019
PubMed

Insights

Daylight photodynamic therapy effectively treated primary cutaneous amyloidosis by generating singlet oxygen, preventing amyloid aggregation. This convenient, cost-effective treatment warrants further investigation in clinical trials.

Area of Science:

  • Dermatology
  • Photochemistry
  • Biochemistry

Background:

  • Primary cutaneous amyloidosis involves extracellular amyloid precursor polymerization into β-pleated sheet fibrils.
  • Amyloid polymerization in Alzheimer's disease models is inhibited by reactive oxygen species.

Observation:

  • Methyl aminolevulinate photodynamic therapy generates singlet oxygen in the skin.
  • This study reports the first case of successful daylight photodynamic therapy for primary cutaneous amyloidosis.

Findings:

  • The therapeutic effect of methyl aminolevulinate photodynamic therapy in primary cutaneous amyloidosis is attributed to a type II photochemical reaction involving singlet oxygen.
  • Daylight photodynamic therapy demonstrated efficacy in treating primary cutaneous amyloidosis in this case report.

Implications:

  • Daylight photodynamic therapy presents a potentially convenient and cost-effective treatment option for primary cutaneous amyloidosis.
  • Further prospective trials are needed to confirm the efficacy and establish the role of daylight photodynamic therapy in managing primary cutaneous amyloidosis.
Keywords:
Photodynamic therapyamyloidosisdepositional disease

More Related Videos

An In Vitro Approach to Photodynamic Therapy04:53

An In Vitro Approach to Photodynamic Therapy

Published on: August 17, 2018

9.4K
Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report10:24

Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report

Published on: February 12, 2018

10.8K

Related Concept Videos

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
1.2K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
Data Reporting and Recording01:24

Data Reporting and Recording

Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
5.4K
Types of Reports I: Hands-off Report01:25

Types of Reports I: Hands-off Report

A hand-off report, also known as a change-of-shift report, is a crucial nursing process that ensures the smooth transition of patient care responsibilities between nursing staff.
Following are the key components and categories of hand-off reports:
Purpose and Process:
1.5K
Types of Reports II: Incident or Occurrence Report01:21

Types of Reports II: Incident or Occurrence Report

An Incident or Occurrence Report in a healthcare setting is a crucial document used to record any unexpected occurrence that may or may not have affected a patient, employee, or visitor. Such reports are critical to improving patient safety and include all details leading up to and including the event.
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...
1.2K
Group Therapy01:26

Group Therapy

Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
423