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Pseudomyxoma Peritonei: Presentation of Two Cases and Challenging Issues in the Literature

Eirini V Pantiora1, Dimitrios Massaras1, John Koutalas2

  • 1Surgery, Aretaieio Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, GRC.

Cureus
|February 26, 2019
PubMed

Insights

Pseudomyxoma peritonei (PMP), a rare oncology syndrome, typically presents with vague symptoms. However, this study highlights successful treatment of two appendix-derived PMP cases using cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC).

Area of Science:

  • Oncology
  • Gastroenterology

Background:

  • Pseudomyxoma peritonei (PMP) is a rare oncology syndrome with an incidence of 1-2 cases per million annually.
  • PMP often presents with nonspecific symptoms like abdominal pain, distention, ascites, or bowel obstruction.

Observation:

  • This report details two cases of PMP originating from the appendix with atypical clinical presentations.
  • Both cases were successfully managed using cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC).

Findings:

  • Cytoreduction and HIPEC demonstrate satisfactory survival rates for PMP, even with unusual presentations.
  • The study emphasizes the importance of raising clinical suspicion for PMP.

Implications:

  • Early diagnosis and appropriate treatment, including cytoreduction and HIPEC, are crucial for managing PMP.
  • Further discussion on the origin and classification of PMP is warranted to address challenging issues in its management.
Keywords:
appendiceal neoplasmclassificationcytoreductive surgeryhipecintraperitoneal hyperthermiapseudomyxoma peritonei

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