Related Experiment Video

Updated: Jan 28, 2026

In Vivo Real-Time Study of Drug Effects on Carotid Blood Flow in the Ovine Fetus
11:59

In Vivo Real-Time Study of Drug Effects on Carotid Blood Flow in the Ovine Fetus

Published on: April 28, 2023

638

Death of a Fetus With Myeloproliferative Disorder and Trisomy 21

Danielle Prentice, Raymond Deiter, John Stanley

    The Journal of the American Osteopathic Association
    |February 26, 2019
    PubMed

    A 27-year-old woman, gravida 2, para 1, presented at 24 weeks gestation with an intrauterine death. She previously consulted with maternal-fetal medicine because of a high suspicion of trisomy 21 after abnormal maternal serum screen and cell-free DNA test results. The patient elected to have chromosomal analysis following the death of the fetus, which confirmed a trisomy 21 diagnosis. Placental pathologic findings suggested that the cause of fetal death was total occlusion of the major vessels due to the accumulation of myeloid precursor cells, a novel mechanism. This case report discusses the rare finding of myeloproliferative disorder as a cause of death of a fetus with trisomy 21.

    More Related Videos

    Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm08:12

    Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm

    Published on: December 22, 2016

    12.4K
    A β-glucuronidase GUS Based Cell Death Assay07:35

    A β-glucuronidase GUS Based Cell Death Assay

    Published on: May 6, 2011

    28.7K

    Related Concept Videos

    Development of the Sexual Organs in the Embryo and Fetus01:15

    Development of the Sexual Organs in the Embryo and Fetus

    Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
    Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
    3.6K
    Intrinsically Disordered Proteins02:18

    Intrinsically Disordered Proteins

    Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
    19.4K
    Autophagic Cell Death01:18

    Autophagic Cell Death

    Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
    Autophagy and Apoptosis
    Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
    4.5K
    Overview of Cell Death01:30

    Overview of Cell Death

    Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
    Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
    9.8K
    Bone Disorders01:29

    Bone Disorders

    Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
    Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
    5.3K
    Disorders of Erythrocytes01:27

    Disorders of Erythrocytes

    Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
    Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
    A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
    On the other...
    2.2K