Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Peptic Ulcer Disease: Injurious Factors01:22

Pathophysiology of Peptic Ulcer Disease: Injurious Factors

1.2K
Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
1.2K
Termination of Translation01:44

Termination of Translation

27.7K
The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
27.7K
Termination of Translation01:44

Termination of Translation

6.8K
6.8K
pH Scale02:41

pH Scale

79.5K
Hydronium and hydroxide ions are present both in pure water and in all aqueous solutions, and their concentrations are inversely proportional as determined by the ion product of water (Kw). The concentrations of these ions in a solution are often critical determinants of the solution’s properties and the chemical behaviors of its other solutes. Two different solutions can differ in their hydronium or hydroxide ion concentrations by a million, billion, or even trillion times. A common means of...
79.5K
Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

2.0K
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
2.0K
Scaling01:26

Scaling

593
In designing and analyzing filters, resonant circuits, or circuit analysis at large, working with standard element values like 1 ohm, 1 henry, or 1 farad can be convenient before scaling these values to more realistic figures. This approach is widely utilized by not employing realistic element values in numerous examples and problems; it simplifies mastering circuit analysis through convenient component values. The complexity of calculations is thereby reduced, with the understanding that...
593

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Skin Health and Persons with Diabetes.

Advances in skin & wound care·2026
Same author

Defining Trombley-Brennan Terminal Tissue Injury With Long-Wave Infrared Thermography.

Advances in skin & wound care·2026
Same author

Improving Care for People Living With Stomas and Ostomies.

Advances in skin & wound care·2026
Same author

Celebrating International Nurses Day 2026.

Advances in skin & wound care·2026
Same author

Skin Cancer and Wound Healing.

Advances in skin & wound care·2026
Same author

Celebrating Pressure Injury Milestones: The Eighth Pressure Injury Themed Issue Welcomes a New NPIAP Partnership.

Advances in skin & wound care·2026

Related Experiment Video

Updated: Jan 28, 2026

Mouse Model of Pressure Ulcers After Spinal Cord Injury
06:51

Mouse Model of Pressure Ulcers After Spinal Cord Injury

Published on: March 9, 2019

10.1K

Reexamining the Literature on Terminal Ulcers, SCALE, Skin Failure, and Unavoidable Pressure Injuries.

Elizabeth A Ayello1, Jeffrey M Levine, Diane Langemo

  • 1Elizabeth A. Ayello, PhD, RN, CWON, ETN, MAPWCA, FAAN • Faculty • Excelsior College School of Nursing • Albany, New York • President • Ayello Harris & Associates, Inc • Copake, New York • President • World Council of Enterostomal Therapists • Co-Editor-in-Chief • Advances in Skin & Wound Care • Philadelphia, Pennsylvania Jeffrey M. Levine, MD, AGSF, CMD • Associate Clinical Professor of Geriatrics and Palliative Care • Icahn School of Medicine at Mount Sinai • New York, New York Diane Langemo, PhD, RN, FAAN • President • Langemo & Associates • Professor Emeritus and Adjunct Professor • University of North Dakota College of Nursing • Grand Forks, North Dakota Karen Lou Kennedy-Evans, RN, FNP, APRN-BC • Wound Consultant • Foothills Rehabilitation Center • Tucson, Arizona Mary R. Brennan, MBA, RN, CWON • Assistant Director for Wound and Ostomy Care • North Shore University Hospital • Manhasset, New York R. Gary Sibbald, MD, DSc (Hons), MEd, FRCPC (Med Derm), ABIM, FAAD, MAPWCA • Professor • Medicine and Public Health • University of Toronto • Toronto, Ontario, Canada • Director • International Interprofessional Wound Care Course and Masters of Science in Community Health (Prevention and Wound Care) • Dalla Lana School of Public Health • University of Toronto • Project Lead • ECHO Ontario, Wound & Skin Care • Previous President • World Union of Wound Healing Societies • co-Editor-in-Chief • Advances in Skin and Wound Care • Philadelphia, Pennsylvania.

Advances in Skin & Wound Care
|February 26, 2019
PubMed
Summary
This summary is machine-generated.

End-of-life skin injuries, including Kennedy terminal ulcers and Skin Changes At Life's End, are clarified. The concept of "skin failure" is proposed as a unifying term for these conditions, distinct from pressure injuries.

More Related Videos

A Pulmonary Trunk Banding Model of Pressure Overload Induced Right Ventricular Hypertrophy and Failure
06:47

A Pulmonary Trunk Banding Model of Pressure Overload Induced Right Ventricular Hypertrophy and Failure

Published on: November 29, 2018

10.1K
Author Spotlight: Investigating the Underlying Mechanisms of Right Ventricular Failure in Pulmonary Hypertension
04:49

Author Spotlight: Investigating the Underlying Mechanisms of Right Ventricular Failure in Pulmonary Hypertension

Published on: June 14, 2024

1.2K

Related Experiment Videos

Last Updated: Jan 28, 2026

Mouse Model of Pressure Ulcers After Spinal Cord Injury
06:51

Mouse Model of Pressure Ulcers After Spinal Cord Injury

Published on: March 9, 2019

10.1K
A Pulmonary Trunk Banding Model of Pressure Overload Induced Right Ventricular Hypertrophy and Failure
06:47

A Pulmonary Trunk Banding Model of Pressure Overload Induced Right Ventricular Hypertrophy and Failure

Published on: November 29, 2018

10.1K
Author Spotlight: Investigating the Underlying Mechanisms of Right Ventricular Failure in Pulmonary Hypertension
04:49

Author Spotlight: Investigating the Underlying Mechanisms of Right Ventricular Failure in Pulmonary Hypertension

Published on: June 14, 2024

1.2K

Area of Science:

  • Integrative medicine
  • Palliative care
  • Wound care

Background:

  • Healthcare professionals require clear terminology for end-of-life skin conditions.
  • Existing terms for terminal skin injuries lack consensus.
  • Distinguishing between pressure injuries and end-of-life skin changes is crucial.

Purpose of the Study:

  • To synthesize literature on end-of-life skin injuries.
  • To clarify terminology surrounding these conditions.
  • To propose a unifying concept of "skin failure".

Main Methods:

  • Literature synthesis on terminal skin injuries.
  • Analysis of terms like Kennedy terminal ulcers, Skin Changes At Life's End, and Trombley-Brennan terminal tissue injuries.
  • Discussion of pressure injury classifications by CMS and NPUAP.

Main Results:

  • Multiple terms exist for end-of-life skin injuries, causing confusion.
  • A unifying concept of "skin failure" is proposed, potentially occurring with acute or chronic illness, or during the dying process.
  • Skin failure is etiologically distinct from pressure injuries, though they can coexist.

Conclusions:

  • The proposed concept of skin failure requires further research and validated criteria.
  • Consensus on terminology is essential for reducing confusion and ensuring appropriate patient care.
  • Further research is needed to establish diagnostic criteria for skin failure.