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Published on: February 23, 2024
Hyperbaric Oxygen Therapy for Second-Degree Burn Healing: An Experimental Study in Rabbits
Mendy J Hatibie1, Andi A Islam, Mochammad Hatta
1In Indonesia, Mendy J. Hatibie, MD, is Head of the Division of Plastic Surgery, University of Sam Ratulangi, Faculty of Medicine, Manado; Andi A. Islam, MD, PhD, is Dean and Professor, Department of Surgery, University of Hasanuddin, Faculty of Medicine, Makassar; Mochammad Hatta, MD, PhD, is Head of the Molecular Biology and Immunology Laboratory, University of Hasanuddin, Faculty of Medicine, Makassar; Yefta Moenadjat, MD, PhD is a Lecturer, Department of Surgery, University of Indonesia, Faculty of Medicine, Jakarta; Rudy H. Susilo, MD, is a general surgeon, Department of Surgery, University of Sam Ratulangi, Faculty of Medicine, Manado; and Leo Rendy, MD, is a general surgeon, Department of Surgery, University of Sam Ratulangi, Faculty of Medicine, Manado. The authors have disclosed no financial relationships related to this article. Submitted August 25, 2018; accepted in revised form October 9, 2018.
Hyperbaric oxygen therapy (HBOT) enhanced healing in rabbit burn models. HBOT improved inflammatory cell migration and epithelialization, crucial for wound repair.
Area of Science:
- Biomedical research
- Wound healing science
Background:
- Wound healing involves inflammation, proliferation, and remodeling.
- Key features include inflammation, neoangiogenesis, and epithelialization.
- Hyperbaric oxygen therapy (HBOT) is a potential treatment to enhance wound repair.
Purpose of the Study:
- To investigate HBOT's efficacy in improving burn wound healing.
- To assess HBOT's impact on specific wound healing features in rabbits.
Main Methods:
- An experimental study involving 36 rabbits with second-degree burns.
- Two groups were established: a control group (n=18) and an HBOT group (n=18).
- The HBOT group received treatment at 2.4 atmospheres absolute for 6 days.
Main Results:
- The HBOT group exhibited significantly increased inflammatory cells compared to the control group (P = .025).
- Epithelialization was also more robust in the HBOT group (P = .024).
- No significant difference in angiogenesis was observed between the groups (P = .442).
Conclusions:
- HBOT may accelerate second-degree burn healing.
- The therapy appears to enhance healing by promoting inflammatory cell migration and re-epithelialization.
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