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Related Experiment Videos

Exploring the "Preterm Behavioral Phenotype" in Children Born Extremely Preterm.

Alice C Burnett1,2,3,4, George Youssef5,6, Peter J Anderson1,7

  • 1Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia.

Journal of Developmental and Behavioral Pediatrics : JDBP
|February 26, 2019
PubMed
Summary

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Children born extremely preterm or with extremely low birth weight show distinct behavioral patterns. Higher symptom levels in these children correlate with poorer cognitive and academic results.

Area of Science:

  • Developmental Psychology
  • Neonatal Research
  • Behavioral Science

Background:

  • Extremely preterm (EP) and extremely low birth weight (ELBW) infants face risks for neurodevelopmental challenges.
  • A 'preterm behavioral phenotype' encompassing emotional, attention, and social difficulties is proposed.
  • Understanding behavioral profiles in EP/ELBW survivors is crucial for targeted interventions.

Purpose of the Study:

  • To investigate the co-occurrence of emotional, attention, and social functioning difficulties in children born EP/ELBW.
  • To identify distinct behavioral profiles among these children.
  • To examine the relationship between these behavioral profiles and cognitive/academic outcomes.

Main Methods:

  • A population-based cohort study of EP/ELBW survivors and matched controls in Victoria, Australia.

Related Experiment Videos

  • Parental ratings of child behavior using the Strengths and Difficulties Questionnaire at 7-8 years.
  • Latent profile analysis to identify behavioral patterns.

    • Main Results:

    • Four distinct behavioral profiles were identified, including minimal difficulties, a preterm behavioral phenotype, and globally elevated symptoms.
    • EP/ELBW children were overrepresented in the preterm behavioral phenotype (20% vs. 12% controls) and globally elevated symptom groups (8% vs. 3%).
    • Higher levels of behavioral symptoms were associated with poorer cognitive and academic performance, independent of birth group and demographics.

    Conclusions:

    • While a preterm behavioral phenotype exists, it is present in only 20% of EP/ELBW children.
    • Behavioral symptom severity is a significant predictor of cognitive and academic outcomes in this population.
    • Further research is needed to understand the underlying mechanisms and develop effective support strategies.