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Hyperbaric oxygen in multiple sclerosis: a double blind trial.

C M Wiles, C R Clarke, H P Irwin

British Medical Journal (Clinical Research Ed.)

|February 8, 1986

Summary

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Hyperbaric oxygen therapy did not show significant benefits for multiple sclerosis patients. This study found no clinical improvement in major outcomes, questioning its use for treating multiple sclerosis.

Area of Science:

Neurology
Oxygen Therapy

Background:

Multiple sclerosis (MS) is a chronic neurological disease.
Hyperbaric oxygen therapy (HBOT) is explored for various conditions.

Purpose of the Study:

To evaluate the efficacy of hyperbaric oxygen therapy in treating multiple sclerosis.

Main Methods:

Eighty-four MS patients received HBOT or placebo in a double-blind study.
Assessments included subjective opinions, disability scales, and functional tests before, during, and after treatment.

Main Results:

No significant clinical benefit was observed in major outcome criteria for HBOT compared to placebo.
Minor improvements in sensory scores and left-hand writing speed were noted but lacked clinical correlation.

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Conclusions:

Hyperbaric oxygen therapy is not recommended for treating multiple sclerosis based on current evidence.
Further research may be needed to explore specific subgroups or outcomes, but broad recommendations are unwarranted.