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Gaseous signaling molecules and their application in resistant cancer treatment: from invisible to visible

Qingbin Cui1,2, Yuqi Yang2, Ning Ji2,3

  • 1School of Public Health, Guangzhou Medical University, Guangzhou, Guangdong, 511436, PR China.

Future Medicinal Chemistry
|February 26, 2019
PubMed

Insights

Gaseous signaling molecules (GSMs) can reverse cancer multidrug resistance (MDR) with fewer side effects than traditional agents. GSM modulators offer a promising strategy for overcoming chemotherapy resistance in cancer treatment.

Area of Science:

  • Biochemistry and Molecular Biology
  • Cancer Research
  • Pharmacology

Background:

  • Multidrug resistance (MDR) significantly limits chemotherapy efficacy.
  • Existing MDR reversal agents often cause severe toxicity, hindering clinical application.
  • Gaseous signaling molecules (GSMs) are endogenous, biocompatible regulators of cellular functions, including MDR.

Purpose of the Study:

  • To review the role of four key GSMs (oxygen, nitric oxide, hydrogen sulfide, carbon monoxide) in modulating cancer MDR.
  • To summarize GSM modulators as potential therapeutic agents for drug-resistant cancers.

Main Methods:

  • Literature review of research on GSMs and their effects on MDR.
  • Analysis of studies involving pharmaceutical formulations of GSMs and GSM-donors.
  • Evaluation of clinical trial data and preclinical research on GSM modulators.

Main Results:

  • GSMs play crucial roles in regulating cellular processes relevant to MDR.
  • GSM modulators, including combined therapies and GSM-releasing molecules, demonstrate potential in overcoming MDR.
  • GSMs exhibit low toxicity compared to conventional chemosensitizing agents.

Conclusions:

  • GSMs represent a novel class of compounds for reversing cancer MDR.
  • GSM modulators offer a safer and potentially more effective approach to treating drug-resistant cancers.
  • Further research into GSM-based therapies is warranted for clinical translation.
Keywords:
cancer treatmentgaseous signaling moleculesmultidrug resistancesensitizing agents

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