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Updated: Jan 28, 2026

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
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Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Published on: August 1, 2018

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An update on cirrhotic cardiomyopathy

Søren Møller1, Karen V Danielsen1,2, Signe Wiese1,2

  • 1a Department of Clinical Physiology and Nuclear Medicine, Center for Functional and Diagnostic Imaging and Research, Hvidovre Hospital , University of Copenhagen , Hvidovre , Denmark.

Expert Review of Gastroenterology & Hepatology
|February 26, 2019
PubMed

Insights

Cirrhotic cardiomyopathy, a condition affecting liver disease patients, involves heart dysfunction that impacts survival and treatment outcomes. Early cardiac evaluation is crucial for managing these patients effectively.

Area of Science:

  • Cardiology
  • Hepatology
  • Internal Medicine

Background:

  • Cirrhosis with portal hypertension leads to high mortality.
  • Hyperdynamic circulation and myocardial dysfunction characterize cirrhotic cardiomyopathy.
  • This condition is implicated in hepatic decompensation, suggesting new therapeutic targets.

Purpose of the Study:

  • To review contemporary aspects of cirrhotic cardiomyopathy.
  • To define cirrhotic cardiomyopathy and its diagnostic methods.
  • To discuss its impact on liver disease severity, survival, and treatment outcomes.

Main Methods:

  • Literature search using PubMed with MeSH terms 'cirrhotic' and 'cardiomyopathies'.
  • Definition based on systolic/diastolic dysfunction and electrophysiological abnormalities.
  • Diagnosis via Doppler/Echocardiography or quantitative MRI.

Main Results:

  • Cirrhotic cardiomyopathy is independent of liver disease etiology but linked to severity and survival.
  • Cardiac dysfunction negatively influences outcomes of invasive procedures and liver transplantation.
  • Liver transplantation improves most cirrhotic cardiomyopathy abnormalities.

Conclusions:

  • Cirrhotic cardiomyopathy is a significant factor in liver disease prognosis.
  • Cardiac evaluation is essential before liver transplantation.
  • No specific treatment for cirrhotic cardiomyopathy is currently recommended, but transplantation offers benefits.
Abstract

Keywords:
Cirrhotic cardiomyopathyQT-intervalarterial vasodilatationcardiovascular dysfunctioncirrhosisdiastolic dysfunctionheart failurehyperdynamic circulationliver transplantationportal hypertensionsystolic dysfunction

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