Related Experiment Video
Updated: Jan 28, 2026
09:37
Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
Published on: August 1, 2018
15.5K
An update on cirrhotic cardiomyopathy.
Søren Møller1, Karen V Danielsen1,2, Signe Wiese1,2
1a Department of Clinical Physiology and Nuclear Medicine, Center for Functional and Diagnostic Imaging and Research, Hvidovre Hospital , University of Copenhagen , Hvidovre , Denmark.
Expert Review of Gastroenterology & Hepatology
|February 26, 2019
Summary
Cirrhotic cardiomyopathy, a condition affecting liver disease patients, involves heart dysfunction that impacts survival and treatment outcomes. Early cardiac evaluation is crucial for managing these patients effectively.
Area of Science:
- Cardiology
- Hepatology
- Internal Medicine
Background:
- Cirrhosis with portal hypertension leads to high mortality.
- Hyperdynamic circulation and myocardial dysfunction characterize cirrhotic cardiomyopathy.
- This condition is implicated in hepatic decompensation, suggesting new therapeutic targets.
Purpose of the Study:
- To review contemporary aspects of cirrhotic cardiomyopathy.
- To define cirrhotic cardiomyopathy and its diagnostic methods.
- To discuss its impact on liver disease severity, survival, and treatment outcomes.
Main Methods:
- Literature search using PubMed with MeSH terms 'cirrhotic' and 'cardiomyopathies'.
- Definition based on systolic/diastolic dysfunction and electrophysiological abnormalities.
- Diagnosis via Doppler/Echocardiography or quantitative MRI.
Main Results:
- Cirrhotic cardiomyopathy is independent of liver disease etiology but linked to severity and survival.
- Cardiac dysfunction negatively influences outcomes of invasive procedures and liver transplantation.
- Liver transplantation improves most cirrhotic cardiomyopathy abnormalities.
Conclusions:
- Cirrhotic cardiomyopathy is a significant factor in liver disease prognosis.
- Cardiac evaluation is essential before liver transplantation.
- No specific treatment for cirrhotic cardiomyopathy is currently recommended, but transplantation offers benefits.
Related Concept Videos
01:30Cardiomyopathy II: Dilated Cardiomyopathy
549
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
549
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
467
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
467
01:29Cardiomyopathy IV: Restrictive Cardiomyopathy
519
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
519
01:29Cardiomyopathy V: Interprofessional Care
396
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
396
01:25Cardiomyopathy I: Introduction and Classification
588
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
588
01:29Cardiomyopathy VI: Nursing Management
348
Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
348