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Updated: Jan 28, 2026

In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)
Published on: August 1, 2025
A unique phenotype of T-cell acute lymphoblastic leukemia in a patient with GATA2 haploinsufficiency
Orlando Esparza1, Ana C Xavier2, T Prescott Atkinson3
1Department of Pediatric Hematology, Oncology and Bone Marrow Transplant, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado.
Abstract:
Germline or acquired mutations involving the GATA-binding protein gene (GATA2) have been linked to a variety of clinical conditions. In addition, patients harboring GATA2 mutations have a striking predisposition to develop myeloid malignancies, such as myelodysplastic syndrome or acute myeloid leukemia, but not acute lymphoblastic leukemia (ALL). We report here a unique occurrence of early T-cell precursor ALL in a young child with GATA2 haploinsufficiency.
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