Related Experiment Video

Updated: Jan 28, 2026

Transcutaneous Microcirculatory Imaging in Preterm Neonates
06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

8.5K

Non-invasive assessment of oxidative stress in preterm infants

Carmen Peña-Bautista1, Thierry Durand2, Claire Vigor2

  • 1Neonatal Research Unit, Health Research Institute La Fe, Valencia, Spain.

Free Radical Biology & Medicine
|February 26, 2019
PubMed

Insights

Preterm infants are vulnerable to oxidative stress, leading to health issues. This study explores non-invasive methods to monitor oxidative stress biomarkers, improving infant care and outcomes.

Area of Science:

  • Neonatal Medicine
  • Biochemistry
  • Pediatric Research

Background:

  • Preterm newborns possess an immature antioxidant defense, increasing susceptibility to oxidative stress.
  • Oxygen supplementation during neonatal intensive care unit (NICU) stays can exacerbate oxidative stress.
  • Oxidative damage in preterm infants correlates with increased morbidities, neurodevelopmental issues, and mortality.

Purpose of the Study:

  • To review studies utilizing non-invasive samples for oxidative stress biomarker determination in preterm infants.
  • To identify methods for closer monitoring of preterm infants with greater predictive value.
  • To present a validated high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method for non-invasive biomarker analysis.

Main Methods:

  • Literature review of studies employing non-invasive sampling techniques for oxidative stress biomarkers.
  • Description of a validated HPLC-MS/MS method for analyzing biomarkers in biofluids.
  • Focus on non-invasive and painless sample collection methods.

Main Results:

  • Non-invasive sample analysis for oxidative stress biomarkers is feasible in preterm infants.
  • Certain non-invasive methods show significant predictive value for monitoring infant health.
  • The described HPLC-MS/MS method accurately quantifies reliable biomarkers in easily obtained samples.

Conclusions:

  • Non-invasive monitoring of oxidative stress biomarkers can reduce the need for invasive procedures in the NICU.
  • This approach facilitates closer monitoring and potentially improves outcomes for preterm infants.
  • Validated non-invasive methods, like HPLC-MS/MS, offer a promising alternative for assessing oxidative stress in vulnerable newborns.

Keywords:
BiomarkerDiagnostic techniques and proceduresOxidative stressPrematurityPreterm infantSalivaUrine

More Related Videos

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

588
A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

12.6K

Related Concept Videos

Oxidation Numbers03:14

Oxidation Numbers

In redox reactions, the transfer of electrons occurs between reacting species. Electron transfer is described by a hypothetical number called the oxidation number (or oxidation state). It represents the effective charge of an atom or element, which is assigned using a set of rules.
42.5K
Pyruvate Oxidation01:15

Pyruvate Oxidation

After glycolysis, the charged pyruvate molecules enter the mitochondria via active transport and undergo three enzymatic reactions. These reactions ensure that pyruvate can enter the next metabolic pathway so that energy stored in the pyruvate molecules can be harnessed by the cells.
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
168.7K
Oxidation-Reduction Reactions03:11

Oxidation-Reduction Reactions

Oxidation–Reduction Reactions
75.5K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
283
Responses to Salt Stress02:02

Responses to Salt Stress

Salt stress—which can be triggered by high salt concentrations in a plant’s environment—can significantly affect plant growth and crop production by influencing photosynthesis and the absorption of water and nutrients.
14.5K
Responses to Heat and Cold Stress02:45

Responses to Heat and Cold Stress

Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
14.7K