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Related Experiment Video

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Robotic Cochlear Implantation for Direct Cochlear Access
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Design and In Vivo Verification of a CMOS Bone-Guided Cochlear Implant Microsystem.

Xin-Hong Qian, Yi-Chung Wu, Tzu-Yi Yang

    IEEE Transactions on Bio-Medical Engineering
    |February 26, 2019
    PubMed
    Summary

    This study developed a less invasive bone-guided cochlear implant (BGCI) microsystem for high-frequency hearing loss. Animal tests confirmed successful auditory nerve stimulation and partial preservation of acoustic hearing.

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    Area of Science:

    • Biomedical Engineering
    • Neuroscience
    • Otolaryngology

    Background:

    • High-frequency hearing loss impacts communication and quality of life.
    • Traditional cochlear implants can be invasive and may not preserve residual acoustic hearing.
    • Novel approaches are needed for effective and less invasive hearing restoration.

    Purpose of the Study:

    • To develop and verify a novel CMOS bone-guided cochlear implant (BGCI) microsystem.
    • To target high-frequency hearing loss by placing electrodes on the cochlear bone surface and near the round window.
    • To create a less invasive alternative to traditional cochlear implants.

    Main Methods:

    • Designed a BGCI microsystem with external and implanted units.
    • Utilized a 13.56 MHz wireless system for power and bidirectional data telemetry.
    • Incorporated a voltage doubler/tripler active rectifier for power efficiency.
    • Employed phase-locked loop modulators/demodulators for data transmission.
    • Developed a four-channel high-voltage-tolerant stimulator for the implanted chip.

    Main Results:

    • Electrical tests verified the functionality of the fabricated BGCI microsystem.
    • In vivo animal tests demonstrated evoked auditory brainstem response waveforms.
    • Successful stimulation of auditory nerves was confirmed.
    • Partial preservation of acoustic hearing was observed in animal models.

    Conclusions:

    • The developed BGCI microsystem offers a less invasive approach compared to traditional cochlear implants.
    • This technology shows promise for treating high-frequency hearing loss.
    • The BGCI microsystem effectively stimulates auditory nerves while preserving some acoustic hearing.