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Difficulties in achieving and maintaining the goal of measles elimination in Bulgaria
R Komitova1, A Kevorkyan2, O Boykinova1
1Department of Infectious Diseases, Parasitology and Tropical Medicine, Faculty of Medicine, Medical University, Plovdiv, Bulgaria; Department of Infectious Diseases, "St George" University Hospital, Plovdiv, Bulgaria.
Abstract:
Measles is a disease with almost a hundred year history of existing registration in Bulgaria and has been subject to mass immunization since 1969. In 2017, after a three-year period with a low number of measles cases registered, an epidemic upsurge has been recorded affecting 3 of the total 28 regions in the country. The purpose of this study was to analyze the changes of measles morbidity in Bulgaria over the period of 1921-2017 and focus on the epidemiological characteristics of the last outbreak in the region of Plovdiv in 2017. For the whole period (1921-2017) the average measles morbidity amounts to 157.69%ооо, decreasing from 525.02%ооо in 1921 to 2.32%ооо in 2017, with 99.5% rate of reduction. In the period prior to vaccination the average morbidity was 247.14%ооо while in the vaccination period it was 70.08%ооо. The ARIMA model could be used as a short-term forecast to predict the morbidity rate. Against the background of the downward tendency in morbidity this study reports a small measles outbreak in Plovdiv, involving 141 cases, after three years of no local virus transmission in the country. An unvaccinated child who returned from abroad probably imported the disease. The measles cases were mainly Roma children and a large number of them were infants. The low intensity and prolong course of the outbreak was indicative of relatively high vaccination coverage of the population. To achieve measles elimination goals, efforts must be made to strengthen surveillance and increase the vaccination coverage, targeting children and especially Roma children.
Insights
Measles morbidity in Bulgaria significantly decreased by 99.5% from 1921 to 2017 due to mass immunization. A 2017 outbreak highlighted the need for increased vaccination coverage, especially for Roma children, to achieve measles elimination.
Area of Science:
- Epidemiology
- Public Health
- Immunization
Background:
- Measles has been registered in Bulgaria for nearly a century, with mass immunization implemented since 1969.
- A significant decline in measles morbidity has been observed, but a notable outbreak occurred in 2017.
Purpose of the Study:
- To analyze measles morbidity trends in Bulgaria from 1921 to 2017.
- To investigate the epidemiological characteristics of the 2017 measles outbreak in Plovdiv.
Main Methods:
- Analysis of historical measles morbidity data from 1921-2017.
- Epidemiological investigation of the 2017 Plovdiv outbreak.
- Application of ARIMA model for short-term morbidity forecasting.
Main Results:
- Measles morbidity decreased by 99.5% from 525.02%ооо in 1921 to 2.32%ооо in 2017.
- The 2017 Plovdiv outbreak involved 141 cases, primarily unvaccinated Roma children and infants.
- The outbreak's characteristics suggest relatively high overall vaccination coverage despite imported cases.
Conclusions:
- Mass immunization has drastically reduced measles morbidity in Bulgaria.
- Targeted efforts to increase vaccination coverage, particularly among Roma children, are crucial for measles elimination.
- Enhanced surveillance and vaccination strategies are necessary to prevent future outbreaks.
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