Related Experiment Video
Updated: Jan 28, 2026

Fabrication and Implementation of a Reference-Free Traction Force Microscopy Platform
Published on: October 6, 2019
Implementation of Institutional Size-Specific Diagnostic Reference Levels for CT Angiography
Yan Klosterkemper1, Christoph Thomas1, Oliver T Bethge1
1University Duesseldorf, Department of Diagnostic and Interventional Radiology, Moorenstraße 5, 40225 Duesseldorf, Germany.
Institutional size-specific diagnostic reference levels (DRLs) for computed tomography angiography (CTA) improve radiation dose analysis. Size-specific DRLs identified more dose outliers in small patients compared to national size-independent DRLs.
Area of Science:
- Radiology and Imaging
- Medical Physics
Background:
- Computed tomography angiography (CTA) examinations are crucial for diagnosing vascular diseases.
- Establishing appropriate radiation dose levels is essential for patient safety and effective imaging.
- Current national diagnostic reference levels (DRLs) are often size-independent, potentially leading to suboptimal dose assessments for individual patients.
Purpose of the Study:
- To develop institutional size-specific DRLs for CTA examinations of the aorta, pulmonary arteries, and pelvis/lower extremity.
- To evaluate the effectiveness of size-specific DRLs in identifying radiation dose outliers compared to size-independent DRLs.
Main Methods:
- A retrospective analysis of 1344 CTA examinations was conducted.
- Water equivalent diameter (Dw) was calculated for each patient to determine body size.
- The relationship between Dw and computed tomography dose index (CTDIvol) was analyzed to establish institutional DRLs at the 75th percentile.
Main Results:
- A strong linear correlation was observed between Dw and CTDIvol across all CTA protocols (R² > 0.93).
- Institutional DRLs were found to be lower than national size-independent DRLs for average-sized patients.
- Size-specific DRLs identified a significantly higher proportion of dose outliers in small patients (56.4%) compared to size-independent DRLs (16.2%).
Conclusions:
- Institutional size-specific DRLs provide a more precise method for analyzing radiation doses in CTA examinations.
- Implementing size-specific DRLs can enhance radiation dose optimization and patient safety by better identifying individuals receiving excessive radiation exposure.
Related Concept Videos
Nursing Implementation
The five steps to implementing effective nursing care include reassessing the patient, reviewing and revising the existing nursing care plan, organizing the resources and care delivery, anticipating and preventing complications, and implementing nursing interventions.
Inertial Frames of Reference
Non-inertial Frames of Reference
Chemical Shift: Internal References and Solvent Effects
The internal reference compound generally used in NMR spectroscopy is tetramethylsilane (TMS). TMS is preferred because it is chemically inert, soluble in NMR solvents, and easily removable. Also, the highly shielded methyl protons in TMS yield an intense...
Cell Size
Surface Area
Cells can take in nutrients and water via diffusion through the plasma membrane itself or through specific channels in the membrane. The area of the membrane surrounding...
Leveling Effect

