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Updated: Jan 28, 2026

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function
Published on: April 17, 2020
Post-esophagectomy Adjuvant Chemotherapy Benefits Esophageal Cancer Patients
Makoto Sohda1, Hideyuki Saito2, Kengo Kuriyama2
1Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Japan msohda@gunma-u.ac.jp.
Background/Aim:
Postoperative chemotherapy is an absolutely imperative treatment for advanced esophageal cancer patients, while preoperative chemotherapy is the standard therapy for clinical stage II/III esophageal squamous cell carcinoma (ESCC) in Japan. The aim of this study was to report the effect of postoperative chemotherapy on survival after esophagectomy due to thoracic esophageal squamous cell carcinoma.
Patients And Methods:
One hundred thirteen consecutive patients with esophageal carcinoma who underwent esophagectomy were included. Several regiments were performed at various times.
Results:
Adjuvant chemotherapy brought a significantly superior overall survival (p=0.002), although there was no significant difference in cancer-specific survival (p=0.054) for clinical stage II or stage III esophageal cancer patients. Depth of invasion (p=0.003), number of lymph node metastases (p=0.048), and venous invasion (p<0.001) were risk factors for recurrence in the adjuvant-chemotherapy group with positive lymph nodes. Additionally, a not well-differentiated type, lymphatic and venous invasions were risk factors for recurrence in the surgery-alone group without positive lymph nodes.
Conclusion:
Postoperative adjuvant chemotherapy contributes to the prognosis of clinical stage II or III esophageal cancer patients.
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