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Updated: Jan 28, 2026

Partial Hepatectomy in Adult Zebrafish
Published on: April 4, 2021
Severe Encephalopathy, Lactic Acidosis and Hyperammonaemia With FOLFIRI Plus Aflibercept After Two-stage Hepatectomy:
Yoshihiro Hara1, Yuji Miyamoto1, Yukiharu Hiyoshi1
1Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Background/Aim:
Recent advances in chemotherapy have increased the possibility of conversion hepatectomy for patients with initially unresectable liver metastases. Although long-term chemotherapy and subsequent extensive hepatectomy are becoming more common, the toxicities of such chemotherapies are unclear.
Patients And Methods:
We present a case report of a patient with metastatic colorectal cancer who developed severe encephalopathy with lactic acidosis and hyperammonaemia caused by 5-fluorouracil-based chemotherapy. Administration of vitamin B1 and continuous haemodiafiltration rapidly improved the patient's symptoms.
Conclusion:
Intensive treatment of metastatic colorectal cancer patients with 5-fluorouracil can induce rare adverse events.
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