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Related Concept Videos

Electron Paramagnetic Resonance (EPR) Spectroscopy: Organic Radicals01:17

Electron Paramagnetic Resonance (EPR) Spectroscopy: Organic Radicals

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Ideally, an unpaired electron shows a single peak in the EPR spectrum due to the transition between the two spin energy states. However, coupling interactions can occur between the spins of the unpaired electron and any neighboring spin-active nuclei. This hyperfine coupling results in hyperfine splitting, where the EPR signal is split into multiplets. The signals split into 2nI + 1 peaks, where n is the number of equivalent nuclei and I is the nuclear spin. These splitting patterns provide...
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There are two main infrared (IR) spectrophotometers: dispersive IR spectrometers and Fourier transform infrared (FTIR) spectrometers. In a dispersive IR spectrometer, a beam of infrared radiation produced by a hot wire is divided into two parallel equal-intensity beams using mirrors. One beam passes through the sample, while another is a reference beam. The beams then move through the monochromator, which separates the radiations into a continuous spectrum of different frequencies. The...
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Paramagnetism01:30

Paramagnetism

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Paramagnets are materials with unpaired electrons that possess a finite magnetic moment. In the absence of a magnetic field, these moments are randomly oriented, and thus the net moment is zero. Under an external field, a torque acting on the moments tends to align them along the field's direction. However, the random thermal motion of electrons produces a torque opposite to the external field and tries to disorient the moments. These two competing effects align only a few moments along the...
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Resonance

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The Lewis structure of a nitrite anion (NO2−) may actually be drawn in two different ways, distinguished by the locations of the N-O and N=O bonds.
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Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Mass Spectrometers

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This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:
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Related Experiment Video

Updated: Jan 28, 2026

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
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Tabletop 700 MHz electron paramagnetic resonance imaging spectrometer.

Laura A Buchanan1, George A Rinard2, Richard W Quine2

  • 1Department of Chemistry and Biochemistry and Center for EPR Imaging of In Vivo Physiology, University of Denver, Denver, CO 80210.

Concepts in Magnetic Resonance. Part B, Magnetic Resonance Engineering
|February 27, 2019
PubMed
Summary

This study introduces a novel table-top electron paramagnetic resonance imaging spectrometer. The device enables rapid, non-invasive measurement of tumor physiology for pre-clinical research.

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Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Spectroscopy

Background:

  • Electron paramagnetic resonance (EPR) imaging offers non-invasive tumor physiology assessment.
  • Existing EPR systems can be large and complex, limiting accessibility.

Purpose of the Study:

  • To design and demonstrate a compact, table-top EPR imaging spectrometer.
  • To enable rapid spectral-spatial imaging at low frequencies.

Main Methods:

  • Development of a 700 MHz table-top EPR imager.
  • Utilized an arbitrary waveform generator and a 25mm cross-loop resonator.
  • Implemented rapid scan and pulse sequences for data acquisition.

Main Results:

  • Successfully generated two and four-dimensional spectral-spatial EPR images.
  • Demonstrated the functionality of the table-top imager prototype.
  • Achieved rapid scanning capabilities at 700 MHz.

Conclusions:

  • The developed table-top EPR imager is a viable prototype for pre-clinical applications.
  • This technology can advance non-invasive tumor characterization.
  • The system facilitates rapid, detailed physiological status assessment.