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Digit Tip Injuries: Current Treatment and Future Regenerative Paradigms
Travis J Miller1,2, Peter L Deptula1, Gregory M Buncke2
1Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94304, USA.
Stem Cells International
|February 27, 2019
Summary
Mammals, including humans, can regenerate digit tips, a capacity observed in simpler organisms. However, applying regenerative medicine for clinical digit amputation treatment remains a challenge.
Area of Science:
- Regenerative medicine
- Developmental biology
- Tissue engineering
Background:
- Understanding of tissue regeneration has grown significantly, inspired by lower organisms like hydra and urodeles.
- Mammals possess inherent regenerative abilities, notably the capacity for distal phalange regeneration after digit amputation.
Purpose of the Study:
- To review the current knowledge of digit tip regeneration.
- To identify barriers in translating regenerative medicine into clinical practice for digit amputation injuries.
Main Methods:
- Literature review of studies on tissue regeneration and digit tip healing.
- Analysis of regenerative paradigms in model organisms and mammals.
- Discussion of clinical applications and challenges in regenerative medicine for digit injuries.
Main Results:
- While lower life forms exhibit extensive regeneration, mammals retain limited but significant regenerative capacity in digit tips.
- A knowledge gap exists between regenerative medicine research and its clinical implementation for digit amputation.
Conclusions:
- Further research is needed to bridge the gap between understanding digit regeneration and its clinical application.
- Translating regenerative medicine strategies into effective treatments for digit amputation requires addressing current limitations.
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