Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Doses of 6-hydroxydopamine sufficient to deplete norepinephrine are not sufficient to decrease plasticity in the

P Trombley, E E Allen, J Soyke

    The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
    |January 1, 1986
    PubMed
    Summary

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Diel transcriptional response of a California Current plankton microbiome to light, low iron, and enduring viral infection.

    The ISME journal·2019
    Same author

    Tau positron emission tomography imaging in C9orf72 repeat expansion carriers.

    European journal of neurology·2019
    Same author

    Hearing threshold shifts among military pilots of the Israeli Air Force.

    Journal of the Royal Army Medical Corps·2017
    Same author

    Effects of lipoprotein apheresis on PCSK9 levels.

    Atherosclerosis. Supplements·2015
    Same author

    Sex differences in the association between body mass index and hypertension - a cross-sectional study in 717 812 adolescents.

    Pediatric obesity·2015
    Same author

    Bisphenol diglycidyl ethers and bisphenol A and their hydrolysis in drinking water.

    Water research·2014

    High doses of 6-hydroxydopamine (6-OHDA) in kittens altered visual cortex plasticity. However, this effect was not directly caused by norepinephrine depletion, challenging previous hypotheses.

    Area of Science:

    • Neuroscience
    • Neurobiology
    • Visual Cortex Plasticity

    Background:

    • Kasamatsu and Pettigrew hypothesized that visual cortex plasticity depends on norepinephrine (NE).
    • Previous research suggested NE is crucial for experience-dependent plasticity in the visual cortex.

    Purpose of the Study:

    • To investigate the role of cortical norepinephrine (NE) in visual cortex plasticity.
    • To test if 6-hydroxydopamine (6-OHDA) induced alterations in plasticity are due to NE depletion.

    Main Methods:

    • Kittens received intraventricular injections of 6-hydroxydopamine (6-OHDA) or vehicle.
    • Monocular visual deprivation was performed in 6-week-old kittens.
    • Cortical NE levels were measured using high-performance liquid chromatography.
    • The ability of the deprived eye to drive cortical cells was assessed.

    Related Experiment Videos

    Main Results:

    • Low dose (0.2 mg) 6-OHDA depleted NE but did not affect cortical plasticity.
    • High dose (4.8 mg) 6-OHDA decreased cortical plasticity.
    • The observed decrease in plasticity was less pronounced than previously reported.

    Conclusions:

    • 6-hydroxydopamine (6-OHDA) can modify visual cortex plasticity.
    • The reduction in plasticity is not solely a consequence of norepinephrine depletion.
    • The findings suggest a more complex mechanism underlying NE's role in cortical plasticity.