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Plaquing of Herpes Simplex Viruses
Published on: November 5, 2021
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Approach to recurrent Herpes Simplex Encephalitis in children.
Abdulrahman Alsweed1,2, Mohammed Alsuhibani1,3, Jean-Laurent Casanova4,5,6,7,8
1Department of Pediatrics, Section of Infectious Disease, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
International Journal of Pediatrics & Adolescent Medicine
|February 27, 2019
Summary
Recurrent Herpes Simplex Encephalitis (HSE) affects up to 5% of patients, often without immune compromise. Genetic factors may predispose individuals to HSE relapses, highlighting the need for early diagnosis and treatment.
Area of Science:
- Neurology
- Virology
- Genetics
Background:
- Herpes Simplex Encephalitis (HSE) is a common viral encephalitis.
- Recurrent HSE is increasingly reported, with relapse rates up to 5%.
- Herpes simplex virus type 1 (HSV-1) is known for nervous system invasion, latency, and recurrence.
Purpose of the Study:
- To review gene mutations predisposing to recurrent HSE.
- To emphasize the importance of early diagnosis and treatment for recurrent HSE.
Main Methods:
- Literature review of genetic predispositions to recurrent HSE.
- Analysis of existing reports on HSE recurrence and host vulnerability.
Main Results:
- Recurrent HSE occurs even in individuals without apparent immune impairment.
- Genetic predispositions are suggested as a factor in host vulnerability to recurrent HSE.
Conclusions:
- Genetic factors may play a significant role in recurrent HSE.
- Early diagnosis and prompt treatment are crucial for managing recurrent HSE.
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