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Molecular profiling and targeted therapy in pediatric gliomas: review and consensus recommendations

Zachary Miklja1, Amy Pasternak2, Stefanie Stallard1

  • 1University of Michigan Medical School, Ann Arbor, Michigan.

Neuro-Oncology
|February 27, 2019
PubMed

Insights

Next-generation sequencing is now recommended for most pediatric gliomas. This precision diagnostic approach improves the standard of care for children and young adults with brain tumors.

Area of Science:

  • Neuro-oncology
  • Pediatric oncology
  • Molecular diagnostics

Background:

  • Advances in neuro-oncology are identifying key oncogenic drivers in pediatric glioma.
  • Precision diagnostics and therapies are rapidly evolving, impacting the standard of care for pediatric brain tumor patients.

Purpose of the Study:

  • To provide consensus recommendations for integrating precision diagnostics and therapeutics into pediatric neuro-oncology.
  • To highlight the utility of molecular profiling in pediatric brain tumors.

Main Methods:

  • Synthesis of data from four recent studies at major academic centers.
  • Review of clinically integrated molecular profiling and targeting strategies for pediatric brain tumors.

Main Results:

  • Four studies demonstrated the feasibility and utility of incorporating sequencing into the care of pediatric brain tumors.
  • Next-generation sequencing is particularly beneficial for children and young adults with glioma.

Conclusions:

  • Next-generation sequencing should be routinely included in the workup of most pediatric gliomas.
  • Integration of precision diagnostics and therapeutics is crucial for improving clinical management.
Keywords:
high-grade gliomalow-grade gliomanext-generation sequencingpediatricprecision medicine

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