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Cholestasis associated with total parenteral nutrition
Journal of Pediatric Gastroenterology and Nutrition
|January 1, 1986
Summary
Neonates, particularly those with very low birthweights, face high risks of cholestasis from total parenteral nutrition (TPN). Early enteral feedings, even minimal ones, may help prevent or treat this TPN-associated liver issue.
Area of Science:
- Neonatalogy
- Pediatric Gastroenterology
- Clinical Nutrition
Background:
- Neonates, especially premature infants with very low birthweights, are at significant risk for cholestasis.
- Cholestasis is a serious complication associated with total parenteral nutrition (TPN), a method of intravenous feeding.
Purpose of the Study:
- To explore the risks and potential preventative strategies for TPN-associated cholestasis in neonates.
- To investigate the role of early enteral nutrition in mitigating cholestasis in infants receiving TPN.
Main Methods:
- Review of existing literature and clinical observations regarding TPN in neonates.
- Analysis of the physiological impact of fasting and the introduction of enteral feedings.
Main Results:
- Early initiation of enteral feedings, within two weeks of starting TPN, appears beneficial in preventing or reducing cholestasis.
- The nutritional content of early enteral feedings may be less critical than the act of feeding itself to interrupt fasting physiology.
Conclusions:
- Enteral feeding should be introduced early in neonates receiving TPN to prevent cholestasis.
- Further research is needed to understand TPN-associated cholestasis pathogenesis and to establish safe and effective prophylactic and therapeutic strategies.