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Device-induced platelet dysfunction in mechanically assisted circulation increases the risks of thrombosis and

Zengsheng Chen1, Jiafeng Zhang1, Kafayat Kareem1

  • 1Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.

Artificial Organs
|February 27, 2019
PubMed
Summary

Mechanical circulatory support (MCS) devices like the CentriMag pump activate platelets, increasing their adhesion to fibrinogen but reducing their interaction with collagen and VWF. This dual effect on platelet function and von Willebrand factor (VWF) may explain simultaneous thrombosis and bleeding risks in patients.

Keywords:
continuous flow ventricular assist devicehemostasis dysfunctionhigh mechanical shear stressplateletvon Willebrand factor

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