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Fatal intoxication with new synthetic cannabinoids AMB-FUBINACA and EMB-FUBINACA
Piotr Adamowicz1, Ewa Meissner2, Marta Maślanka1
1Institute of Forensic Research , Krakow , Poland.
Clinical Toxicology (Philadelphia, Pa.)
|February 27, 2019
Summary
Synthetic cannabinoids AMB-FUBINACA and EMB-FUBINACA were found in autopsy tissues but not blood in a fatal case. This highlights the importance of analyzing multiple tissues for accurate intoxication assessment.
Area of Science:
- Forensic Toxicology
- Pharmacology
Background:
- Synthetic cannabinoids represent a significant and evolving group of novel psychoactive substances.
- AMB-FUBINACA and EMB-FUBINACA are among the newer synthetic cannabinoids appearing on the illicit drug market.
Observation:
- A 27-year-old male was found deceased, with autopsy revealing signs of acute respiratory failure.
- Toxicological analysis was performed on various autopsy materials, including blood, urine, and solid organs.
Findings:
- AMB-FUBINACA and EMB-FUBINACA were detected in all tested post-mortem tissues except blood.
- Highest concentrations were found in stomach contents, suggesting potential oral administration.
- Detected concentrations in solid tissues ranged from 0.2-0.9 ng/g for AMB-FUBINACA and 0.2-3.5 ng/g for EMB-FUBINACA.
Implications:
- The absence of synthetic cannabinoids in blood does not rule out intoxication, necessitating analysis of diverse autopsy samples.
- This case underscores the potential lethality of AMB-FUBINACA and EMB-FUBINACA, contributing to fatal outcomes.
- Forensic investigations must consider a broader range of biological matrices for accurate identification of novel psychoactive substance exposure.
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