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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Tissue Renewal without Stem Cells01:23

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Plant Cells and Tissues02:01

Plant Cells and Tissues

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Plant tissues are collections of similar cells performing related functions. Different plant tissues will have their own specialized roles and can be combined with other tissues to form organs such as flowers, fruit, stem, and leaves. Two major types of plant tissue include meristematic and permanent tissue.
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering
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Scaffold-Free Spheroids Derived from Stem Cells for Tissue-Engineering Applications.

Kaushik U Desai1, Pradnya M Salve1, Neha B Sapkal1

  • 1Institute of Bioinformatics and Biotechnology, Savitribai Phule Pune University, Pune, India.

Critical Reviews in Biomedical Engineering
|February 27, 2019
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Summary

Tissue engineering uses spheroids, not scaffolds, for better cell survival and tissue regeneration. Stem cell spheroids offer new regenerative medicine possibilities by mimicking native tissue environments.

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Scaffold-based tissue engineering faces challenges like foreign body reactions and slow degradation.
  • These limitations can cause inflammation, toxicity, and hinder native tissue regeneration.

Purpose of the Study:

  • To review spheroid fabrication methods for stem cells.
  • To explore the application of stem cell spheroids in regenerative approaches for various tissues and organs.

Main Methods:

  • Focus on various spheroid fabrication techniques.
  • Utilizing stem cells for spheroid formation.
  • Application in regenerative medicine strategies.

Main Results:

  • Spheroids enhance cell survival and cell-to-cell interactions.
  • They provide cellular heterogeneity, nutrient/oxygen gradients, and mimic native tissue conditions.
  • Stem cell spheroids exhibit potential for differentiation into multiple cell lineages.

Conclusions:

  • Stem cell spheroids present a promising alternative to scaffolds in tissue engineering.
  • Spheroids offer superior biological and functional characteristics for regenerative medicine.
  • Further research into spheroid fabrication and application is warranted.