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Parathyroid Hormone and Ischemic Cerebrovascular Event

Hakan Altay1, Cihan Altın1, Ali Coner1

  • 1Department of Cardiology, Faculty of Medicine, Baskent University, Ankara, Turkey.

Endocrine, Metabolic & Immune Disorders Drug Targets
|February 27, 2019
PubMed

Insights

Elevated parathyroid hormone (PTH) levels are linked to increased carotid intima-media thickness (CIMT) and reduced aortic distensibility in patients experiencing ischemic cerebrovascular events (ICVE). This study highlights PTH as a potential biomarker for atherosclerosis in ICVE patients.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Neurology

Background:

  • Elevated parathyroid hormone (PTH) is linked to cardiovascular risk factors like hypertension and left ventricular hypertrophy, which predispose individuals to ischemic cerebrovascular events (ICVE).
  • Carotid intima-media thickness (CIMT) and aortic distensibility are established early indicators of subclinical atherosclerosis.
  • The association between PTH levels and these atherosclerosis markers in ICVE patients remained uninvestigated prior to this study.

Purpose of the Study:

  • To investigate the relationship between parathyroid hormone (PTH) levels and measures of atherosclerosis, specifically CIMT and aortic distensibility, in patients with ICVE.

Main Methods:

  • The study included 64 patients diagnosed with ICVE and a control group of 50 individuals.
  • Parathyroid hormone (PTH) levels, carotid intima-media thickness (CIMT), and aortic distensibility were measured in all participants.

Main Results:

  • Patients with ICVE exhibited significantly higher PTH levels compared to the control group (p=0.008).
  • PTH levels demonstrated a significant inverse correlation with aortic distensibility (r=-0.420, p=0.001).
  • A significant positive correlation was observed between PTH levels and CIMT (r=0.285, p=0.002).

Conclusions:

  • This study demonstrates that individuals with acute ischemic cerebrovascular events have elevated parathyroid hormone (PTH) levels.
  • The findings indicate an inverse relationship between PTH levels and aortic distensibility, and a positive association with CIMT in ICVE patients.
  • Elevated PTH may serve as a potential biomarker for subclinical atherosclerosis in the context of ischemic cerebrovascular events.
Abstract

Keywords:
Parathyroid hormoneaortic distensibilityatherosclerosisatherosclerotic plaquescarotid intima-media thicknesscerebrovascular event.

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