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Updated: Jan 28, 2026

In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)
Published on: August 1, 2025
Congenital B-cell Acute Lymphoblastic Leukemia with Congenital Rubella Infection
Dhan Raj Bagri1, Krapal Singh Yadav2, Rambabu Sharma2
1Department of Pediatrics, Sir Padampat Mother and Child Health Institute, JK Lon Hospital, SMS Medical College, Jaipur, Rajasthan, India. Correspondence to: Dr Dhan Raj Bagri, Departments of Pediatrics, SMS Medical College, Jaipur, Rajasthan, India. meena.drdhanraj6@gmail.com.
Background:
Congenital B-cell Acute lymphoblastic leukemia (ALL) is a rare malignancy.
Characteristics:
A newborn infant presented with purpuric spots and ecchymotic patches, blueberry muffin rash, depressed neonatal reflexes, respiratory distress and hepatosplenomegaly. Peripheral smear revealed atypical blast cells. Serum ELISA was positive for Rubella IgM and IgG antibodies. Flow cytometry suggested congenital B-cell ALL.
Outcome:
The baby died after 3 days due to suspected intracranial hemorrhage.
Message:
Congenital leukemia may be rarely associated with congenital rubella infection.
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