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Catalytic enantioselective iodolactonization reactions.

Renate Kristianslund¹, Jørn Eivind Tungen, Trond Vidar Hansen

¹School of Pharmacy, Department of Pharmaceutical Chemistry, University of Oslo, PO Box 1068 Blindern, N-0316 Oslo, Norway. t.v.hansen@farmasi.uio.no.

Organic & Biomolecular Chemistry

|February 27, 2019

Summary

Catalytic enantioselective iodolactonization reactions offer new ways to create lactones. This review covers recent advances in controlling stereoselectivity for these important chemical transformations.

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Area of Science:

Organic Chemistry
Synthetic Chemistry
Catalysis

Background:

Halolactonization is a key reaction for synthesizing lactones from alkenoic acids or esters.
Traditional methods rely on substrate or reagent control for stereoselectivity.
Substrate-controlled methods are well-established, particularly in natural product synthesis.

Purpose of the Study:

To review recent advancements in catalytic, enantioselective iodolactonization reactions.
To highlight the development of new methods for stereoselective lactone synthesis over the past decade.

Main Methods:

Review of literature focusing on catalytic enantioselective iodolactonizations.
Analysis of substrate scope and reaction conditions for various methods.
Discussion of stereochemical control mechanisms in recent catalytic systems.

Main Results:

Emergence of catalytic methods for enantioselective iodolactonization.
Demonstration of efficient lactone construction with high stereocontrol.
Expansion of the scope beyond traditional substrate-controlled approaches.

Conclusions:

Catalytic enantioselective iodolactonization represents a significant recent development in synthetic organic chemistry.
These methods provide powerful tools for accessing chiral lactones with improved efficiency and selectivity.
The field has seen substantial progress in the last ten years, offering new synthetic strategies.