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Immunotherapy for advanced lung cancer combined with surgery for mediastinal myxofibrosarcoma: a case report
Tetsuya Fukui1, Yusuke Wakatsuki2, Tadashi Matsukura2
1Department of General Thoracic Surgery, Japanese Red Cross Fukui Hospital, 2-4-1 Tsukimi Fukui, Fukui, 918-8501, Japan. tetsuyanarakyoto.medicine@gmail.com.
Background:
It is unclear whether simultaneous primary neoplasm resection and immunotherapy for advanced lung cancer is safe. We report a case of an elderly man with advanced lung cancer and myxofibrosarcoma.
Case Presentation:
The advanced lung cancer was treated with pembrolizumab, and partial response was achieved in 3 months. However, the mediastinal cyst enlarged rapidly. We resected the mediastinal tumor and diagnosed it as myxofibrosarcoma. The postoperative course was uneventful. Immunotherapy was resumed after the operation without any adverse effects. No recurrence of mediastinal sarcoma or progression of lung cancer was found until the patient died in an accident 8 months after surgery.
Conclusion:
Surgery for mediastinal sarcoma could be performed safely in combination with immunotherapy for advanced lung cancer.
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Overview of Advanced Functional Groups
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
Extraction: Advanced Methods

