Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.9K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.9K
Epigenetic Regulation01:46

Epigenetic Regulation

33.7K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.7K
Epigenetic Regulation01:37

Epigenetic Regulation

3.9K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.9K
Cancer Therapies02:49

Cancer Therapies

10.1K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.1K
Gene Therapy00:59

Gene Therapy

27.6K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
Group Therapy01:26

Group Therapy

423
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
423

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Selective inhibition of STAT3 transcriptional activity by novel small molecules alleviates the development of lupus in mice.

Translational research : the journal of laboratory and clinical medicine·2026
Same author

Impact of Artificial Diet Versus Mulberry Leaves on Silkworm Growth, Nutrient Composition, and Gut Microbiota.

Archives of insect biochemistry and physiology·2025
Same author

Divergence between neural and retinal lineage specification during human brain development by signal transduction.

Journal of advanced research·2025
Same author

Improvements in Mechano-Electrochemical Energy Harvesting Performance of Carbon Nanotube Yarns via Poly(sodium 4-styrenesulfonate) Coating.

ACS applied materials & interfaces·2025
Same author

HELLS controls mitochondrial dynamics and genome stability in liver cancer by collusion with MIEF1.

Cell death & disease·2025
Same author

Modeling doxorubicin-induced-cardiotoxicity through breast cancer patient specific iPSC-derived heart organoid.

Heliyon·2024

Related Experiment Video

Updated: Jan 28, 2026

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

1.9K

Targeting epigenetics for cancer therapy.

Jong Woo Park1, Jeung-Whan Han2

  • 1Research Center for Epigenome Regulation, School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.

Archives of Pharmacal Research
|February 27, 2019
PubMed
Summary

Cancer involves epigenetic changes, not just genetic mutations. These epigenetic modifications, including DNA methylation and histone changes, are key to cancer development and offer new therapeutic targets.

Keywords:
Cancer epigeneticsDNA methylationEpigenetic drugsHistone modification

More Related Videos

ATAC-Seq Optimization for Cancer Epigenetics Research
07:13

ATAC-Seq Optimization for Cancer Epigenetics Research

Published on: June 30, 2022

5.3K
Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.5K

Related Experiment Videos

Last Updated: Jan 28, 2026

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

1.9K
ATAC-Seq Optimization for Cancer Epigenetics Research
07:13

ATAC-Seq Optimization for Cancer Epigenetics Research

Published on: June 30, 2022

5.3K
Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.5K

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Cancer is characterized by uncontrolled cell growth and tissue invasion.
  • Genetic aberrations were historically considered the primary cause of cancer.
  • Emerging evidence highlights the crucial role of epigenetic modifications in cancer development.

Purpose of the Study:

  • To review major epigenetic alterations in cancer biology.
  • To summarize epigenetic mechanisms driving tumor initiation, progression, and metastasis.
  • To discuss novel epigenetic therapeutics and biomarkers for cancer treatment.

Main Methods:

  • Review of scientific literature on cancer epigenetics.
  • Analysis of epigenetic mechanisms like DNA methylation, histone modifications, and lncRNAs.
  • Examination of clinical and preclinical data for epigenetic therapies.

Main Results:

  • Epigenetic dysregulation, including aberrant DNA methylation and histone modifications, is central to cancer.
  • Long non-coding RNAs (lncRNAs) play a significant role in cancer progression.
  • Epigenetic alterations provide promising avenues for novel cancer biomarkers and therapeutics.

Conclusions:

  • Epigenetic modifications are fundamental to cancer biology, complementing genetic factors.
  • Understanding cancer epigenetics is crucial for developing targeted therapies.
  • Advances in cancer epigenetics have led to innovative biomarkers and treatments.