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Harpagoside Content in Devil's Claw Extracts.

Narasimharao Kondamudi, Matthew W Turner, Owen M McDougal

    Natural Product Communications
    |February 27, 2019
    PubMed
    Summary
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    Devil's claw supplements from both H. procumbens and H. zeyheri species contain comparable harpagoside levels. This research clarifies the reality of devil's claw (Harpagophytum) chemical composition for consumers.

    Area of Science:

    • Phytochemistry
    • Pharmacognosy
    • Nutraceutical Science

    Background:

    • Devil's claw (Harpagophytum spp.) is widely used in nutraceuticals for arthritis inflammation.
    • Discrepancies exist between industry claims and botanical classification regarding Devil's claw species (H. procumbens vs. H. zeyheri).
    • Bioactive iridoid glycosides, specifically harpagosides, are key compounds in Devil's claw extracts.

    Purpose of the Study:

    • To chemically analyze and compare the harpagoside content in extracts of H. procumbens and H. zeyheri.
    • To determine if harpagoside presence differs between the two species and commercial nutraceutical products.
    • To provide evidence-based information on Devil's claw composition for stakeholders.

    Main Methods:

    • Microwave-assisted extraction of root samples from H. procumbens and H. zeyheri.

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  • High-performance liquid chromatography (HPLC) for quantitative analysis of harpagosides.
  • Comparison of chemical profiles between species and commercial nutraceuticals.

    • Main Results:

    • Harpagoside quantities were found to be similar in root extracts of both H. procumbens and H. zeyheri.
    • While non-harpagoside constituents varied, the primary bioactive harpagoside content was comparable across species.
    • Findings suggest that both species contribute similarly to the harpagoside content in Devil's claw supplements.

    Conclusions:

    • The chemical composition, specifically harpagoside content, is comparable between H. procumbens and H. zeyheri.
    • Botanical classification supports the use of both species generically as Devil's claw in nutraceuticals.
    • This study aims to resolve misconceptions regarding Devil's claw supplements' efficacy and sourcing.