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Updated: Jan 28, 2026

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
Published on: May 25, 2017
Effects of nanoscale electric fields on the histology of liver cell dysplasia
Aya O Balbaa1,2, Ahmed Abd El-Fattah3,4, Nahla M Awad5
1Medical Research Institute, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Abstract:
Cells electrical fields have a significant role in cell function.
Aim:
The current study examined the effects of nanoscale electric fields generated by magneto-electric nanoparticles (MENs) on precancerous liver tissue.
Methods & Results:
A total of 30 nm MENs synthesized by sol-gel method were tested in vitro on HepG2 cells and in vivo on liver cell dysplasia in mice, which were exposed to 50 Hz 2 mT for 2 weeks, +/- MENs. MENs with alternating field (AF) reversed liver cells dysplastic features. In vitro cytotoxicity assay showed high lethal dose (LD 50) of 1.4 mg/ml. We also report on the expression of alpha-fetoprotein and cytochrome C.
Conclusion:
MEN-generated nanoscale electric fields have significant biological effects on precancerous liver cells.
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