A low-pass filter of 300 Hz improved the detection of pacemaker spike on remote and bedside electrocardiogram

Jian Sun1, Qiu-Feng Lu, Yan Zhao

  • 1Department of Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.

Chinese Medical Journal
|February 27, 2019
PubMed
Abstract

Insights

A 300 Hz low-pass filter (LPF) significantly improves pacemaker spike detection on electrocardiograms (ECGs), outperforming the standard 150 Hz cutoff. This enhanced detection accuracy applies to both remote and bedside ECGs, aiding in accurate pacemaker function diagnosis.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Medical Diagnostics

Background:

  • The standard 150 Hz upper-frequency cutoff in electrocardiogram (ECG) filters can lead to the loss of pacemaker spikes, potentially causing misdiagnosis.
  • Investigating alternative low-pass filter (LPF) settings is crucial for improving the accurate detection of pacemaker activity.
  • This study evaluates the impact of various LPF settings on pacemaker spike detection in both remote and bedside ECG recordings.

Purpose of the Study:

  • To determine the optimal upper-frequency cutoff for low-pass filters (LPFs) to enhance pacemaker spike detection on ECGs.
  • To compare the efficacy of different LPF settings (40, 100, 150, 200, 300, and 400 Hz) in identifying atrial and ventricular pacing spikes.
  • To assess whether remote ECG transmission affects the diagnostic performance of different LPF settings.

Main Methods:

  • Collected standard 12-lead ECGs from 88 patients with permanent pacemakers during routine follow-up.
  • Recorded ECGs using six different upper-frequency cutoff settings: 40, 100, 150, 200, 300, and 400 Hz.
  • Analyzed both bedside and remotely transmitted ECGs for atrial and ventricular pacing spikes by two independent medical practitioners, using pacemaker programming as the gold standard.

Main Results:

  • The 300 Hz LPF demonstrated superior performance in detecting atrial-paced spikes on bedside ECGs, with a significantly higher area under the curve (AUC) compared to the 150 Hz filter (0.73 vs. 0.56, P=0.002).
  • For atrial pacing detection using the 300 Hz LPF, sensitivity was 59.4%, specificity 85.7%, positive predictive value 92.7%, and negative predictive value 40.9%.
  • The 300 Hz LPF also showed higher accuracy in detecting ventricular-paced spikes on bedside ECGs (AUC=0.93) compared to the 150 Hz filter (AUC=0.86; P<0.001). Results for remote ECGs were comparable.

Conclusions:

  • A 300 Hz upper-frequency cutoff for LPF is recommended for improved ECG detection of pacemaker spikes.
  • Implementing the 300 Hz LPF allows remote ECGs to achieve diagnostic performance equivalent to bedside ECGs.
  • This finding supports the use of higher LPF settings for more accurate pacemaker function assessment in clinical practice.

Related Concept Videos

First Pass Effect01:12

First Pass Effect

Presystemic elimination, or the first-pass effect, is the metabolism of drugs that reduces their effective concentration at the site of action. Apart from the first-pass effect, the systemic bioavailability of the drug is also reduced by other factors, including incomplete absorption or chemical degradation of drugs.
Depending on the route of administration, drugs can be metabolized in the liver, intestine, lungs, and vasculature. Orally administered drugs are first absorbed through the...
9.2K
Electrocardiogram01:29

Electrocardiogram

An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
6.0K
Electrocardiogram Fundamentals01:28

Electrocardiogram Fundamentals

Introduction
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin...
1.5K
Passive Filters01:27

Passive Filters

Passive filters are utilized to shape the frequency spectrum of signals across a diverse array of applications. These filters, using only passive elements like resistors (R), inductors (L), and capacitors (C), are capable of selectively allowing or blocking certain frequency ranges without the need for external power sources.
Low-Pass Filters
Low-pass filters are designed to transmit signals with frequencies lower than the cutoff frequency, ωc, and attenuate those above it. The cutoff...
1.0K
Active Filters01:25

Active Filters

Active filters are electronic circuits that use operational amplifiers (op-amps), resistors, and capacitors to filter out unwanted frequency components from a signal. A first-order low-pass active filter is designed to pass signals with a frequency lower than a certain cutoff frequency and attenuate frequencies higher than that cutoff frequency. The transfer function for a first-order low-pass active filter is:
1.3K
Single-pass Transmembrane Proteins01:25

Single-pass Transmembrane Proteins

Integral membrane proteins are tightly associated with the cell membrane and play a crucial role in cell communication, signaling, adhesion, and transport of the molecules. Some integral membrane proteins are present only in the membrane monolayer. For example, the enzyme fatty acid amide hydrolase is present in the cytoplasmic side of the membrane monolayer. In contrast, another type of integral membrane protein, also known as a transmembrane protein, spans across the membrane. Transmembrane...
6.6K